mProX™ Human TLR7 Stable Cell Line

Product Information

Target Family

Immune Checkpoint

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;PANC-1

Target Classification

Immune Checkpoint Cell Lines

Target Research Area

immunology Research

Related Diseases

Systemic Lupus Erythematosus 17; Immunodeficiency 74, Covid19-Related, X-Linked

Gene ID

Human:51284

UniProt ID

Human:Q9NYK1

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

Toll-like receptor 7 (TLR7) is primarily known for recognizing single-stranded RNA, commonly found in viruses. Recent research has illuminated its role in various diseases, from viral infections to autoimmune disorders. For instance, enhanced TLR7 signaling has been linked to the aberrant survival of B cells, which can contribute to autoimmune diseases like systemic lupus erythematosus. Furthermore, TLR7's role in recognizing SARS-CoV-2, the virus responsible for COVID-19, has been highlighted, emphasizing its relevance in current global health challenges.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Jordan Davis (Verified Customer)

How does TLR7 interact with viral RNA? Jun 10 2020

chat Patrick Liam (Creative Biolabs Scientific Support)

TLR7 can bind synthetic or viral RNA, suggesting that it may have immune functions mediated by viral RNA. This interaction indicates that red blood cells, expressing TLR7, could potentially be a reservoir for RNA-based diagnostics. Jun 10 2020

chat Jordan Williams (Verified Customer)

What is the role of TLR7 in immune response during influenza infection? Jan 14 2023

chat Patrick Liam (Creative Biolabs Scientific Support)

TLR7 plays a crucial role in activating the type I interferon response in lung epithelial cells during influenza A virus infection. The deletion of β6 integrin enhances TLR7-mediated immune response, indicating its importance in respiratory infections. Jan 14 2023

Published Data

Fig.1 The effective transduction of TLR7 and TLR8 in PANC 1 cells is depicted.

Western blot analysis confirmed enhanced TLR7 and TLR8 protein expression in transduced PANC1 cells. As controls, PANC1 cells transduced with an empty vector were employed. As a control for protein loading, a β-actin control was employed.

Ref: Grimmig, Tanja, et al. "TLR7 and TLR8 expression increases tumor cell proliferation and promotes chemoresistance in human pancreatic cancer." International journal of oncology 47.3 (2015): 857-866.

Pubmed: 26134824

DOI: 10.3892/ijo.2015.3069

Research Highlights

Som, Avik. et al. "Percutaneous Intratumoral Immunoadjuvant Gel Increases The Abscopal Effect of Cryoablation for Checkpoint Inhibitor Resistant Cancer." Advanced healthcare materials, 2023.
Percutaneous cryoablation is a commonly used medical technique for treating both metastatic and primary cancer. While there have been rare cases of this treatment causing a regression of distant metastases, known as the "abscopal" effect, its effectiveness is often limited. One potential solution is the use of intratumoral immunoadjuvants, though current options require frequent injections and lack the ability to confirm successful drug delivery. To address these challenges, a new injectable gel-based formulation called "Imigel" has been developed. This thermoresponsive gel contains the FDA-approved TLR7 agonist imiquimod and a contrast agent for visualization under CT. By using a specialized copolymer gel, this treatment offers improved drug concentration and release rate, requiring only one injection. Further testing has shown its ability to significantly enhance the abscopal effect of cryoablation in aggressive colorectal and breast cancer dual tumor models. In these studies, responders saw complete regression of bilateral tumors in 90 days.
Som, Avik. et al. "Percutaneous Intratumoral Immunoadjuvant Gel Increases The Abscopal Effect of Cryoablation for Checkpoint Inhibitor Resistant Cancer." Advanced healthcare materials, 2023.
Pubmed: 37870153 DOI: 10.1002/adhm.202301848

Du, Yuxuan. et al. "Meta-analysis of the association between toll-like receptor gene polymorphisms and hepatitis C virus infection." Frontiers in microbiology, 2023.
The aim of this study was to examine the potential correlation between hepatitis C virus (HCV) infection and the toll-like receptor (TLR) 3/7 gene polymorphisms.
Du, Yuxuan. et al. "Meta-analysis of the association between toll-like receptor gene polymorphisms and hepatitis C virus infection." Frontiers in microbiology, 2023.
Pubmed: 37869679 DOI: 10.3389/fmicb.2023.1254805