TBK1
The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. The protein is also an important kinase for antiviral innate immunity response.
| Full Name | TANK binding kinase 1 |
| Gene ID | Human: 29110 Mouse: 56480 Rat: 299827 Monkey: 717427 |
| UniProt ID | Human: Q9UHD2 Mouse: Q9WUN2 Rat: D4A7D3 |
| Alternative Names | NAK; T2K; IIAE8; FTDALS4;serine/threonine-protein kinase TBK1;NF-kB-activating kinase;NF-kappa-B-activating kinase |
Product List
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mProX™ Human TBK1 Stable Cell Line
[CAT#: S01YF-1023-PY111]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: HEK293;CHO-K1;A549;H23;H441;H460 Assay Types: Biological assays
mProX™ Human TTBK1 Stable Cell Line
[CAT#: S01YF-1023-PY122]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: HEK293;CHO-K1;Neuro-2a Assay Types: Biological assays
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