mProX™ Human TTBK1 Stable Cell Line

[CAT#: S01YF-1023-PY122]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1222-KX517	Magic™ Human TTBK1 in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;Neuro-2a

Target Classification

Kinase Cell Lines

Target Research Area

CNS Research

Related Diseases

Childhood-Onset Schizophrenia; Spinocerebellar Ataxia 11

Gene ID

Human:84630

UniProt ID

Human:Q5TCY1

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

TTBK1, or Tau-tubulin kinase 1, has various applications in research related to neurodegenerative diseases such as Alzheimer's disease (AD). In one study, antisense oligonucleotide (ASO) targeting TTBK1 was shown to prevent the accumulation of phosphorylated tau in the hippocampus of PS19 tauopathy mice, suggesting its potential as a therapeutic target for delaying the development of tau pathology in AD. Another study found that TTBK1 and CK1 inhibitors could restore TDP-43 pathology and prevent disease propagation in lymphoblasts from AD patients, indicating their potential as therapeutic interventions for AD. Additionally, TTBK1 and TTBK2 were found to regulate ciliogenesis and neural rosette formation in human pluripotent stem cells, suggesting their involvement in embryonic development and tissue homeostasis. Furthermore, the identification of TTBK1 inhibitors through microfluidics-based assays provides a platform for the development of novel inhibitors that could be used for AD prevention. Overall, TTBK1 has implications in the understanding and treatment of neurodegenerative diseases.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Casey Davis (Verified Customer)

What is the significance of TTBK1 in neurodegenerative diseases? Jun 04 2021

chat Patrick Liam (Creative Biolabs Scientific Support)

TTBK1 is implicated in neurodegenerative diseases, as its inhibition can lower tau phosphorylation, which is a key factor in diseases like Alzheimer's. Jun 04 2021

chat Taylor Smith (Verified Customer)

How does TTBK1 affect ciliogenesis? Jun 20 2023

chat Patrick Liam (Creative Biolabs Scientific Support)

TTBK1 plays a crucial role in ciliogenesis, as its modulation impacts the stability and function of cilia. Jun 20 2023

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