mProX™ Human TBK1 Stable Cell Line

[CAT#: S01YF-1023-PY111]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1222-KX500	Magic™ Human TBK1 in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;A549;H23;H441;H460

Target Classification

Kinase Cell Lines

Target Research Area

Infectious Research

Related Diseases

Encephalopathy, Acute, Infection-Induced 8; Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 4

Gene ID

Human:29110

UniProt ID

Human:Q9UHD2

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

TBK1 (TANK-binding kinase 1) is a key kinase involved in the innate immune response against viral infections. It plays a role in the activation of transcription factor IRF3, which is important for antiviral immune response and pathogen clearance. Studies have shown that TBK1 is regulated by various proteins and molecules, including BLK (B lymphoid tyrosine kinase), lncRNA-BTX (long noncoding RNA between Tbk1 and Xpot), SARS-CoV-2 protein ORF3c, and SARS-CoV-2 protein NSP9. These proteins and molecules interact with TBK1 to modulate its activity and downstream signaling pathways, leading to the production of antiviral cytokines and the promotion of viral replication. Targeting TBK1 and its regulators may have therapeutic potential for enhancing viral clearance and controlling cytokine storms associated with viral infections.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Jordan Brown (Verified Customer)

What is the role of TBK1 in immune defense against tumors and viral infections? Dec 14 2022

chat Patrick Liam (Creative Biolabs Scientific Support)

TBK1 recruitment to STING activates both IRF3 and NF-κB pathways, playing a crucial role in immune defense against tumors and viral infections. Dec 14 2022

chat Peyton Jones (Verified Customer)

How does TBK1 interact with SARS-CoV-2? Jun 01 2022

chat Patrick Liam (Creative Biolabs Scientific Support)

SARS-CoV-2 NSP13 inhibits type I interferon production by degrading TBK1 via p62-dependent selective autophagy. Jun 01 2022

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