KIT
This gene encodes a receptor tyrosine kinase. This gene was initially identified as a homolog of the feline sarcoma viral oncogene v-kit and is often referred to as proto-oncogene c-Kit. The canonical form of this glycosylated transmembrane protein has an N-terminal extracellular region with five immunoglobulin-like domains, a transmembrane region, and an intracellular tyrosine kinase domain at the C-terminus. Upon activation by its cytokine ligand, stem cell factor (SCF), this protein phosphorylates multiple intracellular proteins that play a role in in the proliferation, differentiation, migration and apoptosis of many cell types and thereby plays an important role in hematopoiesis, stem cell maintenance, gametogenesis, melanogenesis, and in mast cell development, migration and function. This protein can be a membrane-bound or soluble protein. Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene
| Full Name | KIT proto-oncogene, receptor tyrosine kinase |
| Gene ID | Human: 3815 Mouse: 16590 Rat: 64030 Monkey: 696759 |
| UniProt ID | Human: P10721 Mouse: P05532 Rat: B7SCJ0 |
| Alternative Names | PBT; SCFR; C-Kit; CD117; MASTC;mast/stem cell growth factor receptor Kit;c-Kit protooncogene;p145 c-kit;piebald trait protein;proto-oncogene c-Kit;proto-oncogene tyrosine-protein kinase Kit;tyrosine-protein kinase Kit;v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog;v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein |
Product List
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- Product Category:
- Membrane Protein Tools
- Target Protein: KIT Target Family: Kinases/Enzyme Vector: pBE Vector Type: Bacterial Expression Vector
- Product Category:
- Membrane Protein Tools
- Target Protein: KIT Target Family: Kinases/Enzyme RNA Type: IVT mRNA Formation: In Vitro Transcription (IVT) mRNA
- Product Category:
- Membrane Protein Tools
- Target Protein: KIT Target Family: Kinases/Enzyme Vector: pIVT Vector Type: In Vitro Transcription (IVT) Vector
- Product Category:
- Membrane Protein Tools
- Target Protein: KIT Target Family: Kinases/Enzyme Vector: pIE Vector Type: Insect Expression Vector
- Product Category:
- Membrane Protein Tools
- Target Protein: KIT Target Family: Kinases/Enzyme Vector: pLV Vector Type: Lentiviral Expression Vector
- Product Category:
- Membrane Protein Tools
- Target Protein: KIT Target Family: Kinases/Enzyme
- Product Category:
- Membrane Protein Tools
- Target Protein: KIT Target Family: Kinases/Enzyme RNA Type: LNP-mRNA Formation: LNP Encapsulation mRNA
- Product Category:
- Membrane Protein Tools
- Target Protein: KIT Target Family: Kinases/Enzyme Vector: pME Vector Type: Mammalian Transient Expression Vector
- Product Category:
- Membrane Protein Tools
- Target Protein: KIT Target Family: Kinases/Enzyme Vector: pRV Vector Type: Retroviral Expression Vector
- Product Category:
- Membrane Protein Tools
- Target Protein: KIT Target Family: Kinases/Enzyme Vector: pYE Vector Type: Yeast Expression Vector
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: KIT Target Family: Kinases/Enzyme Drug Discovery Assays and Products Target Protein Species: Human Host Cell Type: CHO-K1; HEK293
