KIT
This gene encodes a receptor tyrosine kinase. This gene was initially identified as a homolog of the feline sarcoma viral oncogene v-kit and is often referred to as proto-oncogene c-Kit. The canonical form of this glycosylated transmembrane protein has an N-terminal extracellular region with five immunoglobulin-like domains, a transmembrane region, and an intracellular tyrosine kinase domain at the C-terminus. Upon activation by its cytokine ligand, stem cell factor (SCF), this protein phosphorylates multiple intracellular proteins that play a role in in the proliferation, differentiation, migration and apoptosis of many cell types and thereby plays an important role in hematopoiesis, stem cell maintenance, gametogenesis, melanogenesis, and in mast cell development, migration and function. This protein can be a membrane-bound or soluble protein. Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene
| Full Name | KIT proto-oncogene, receptor tyrosine kinase |
| Gene ID | Human: 3815 Mouse: 16590 Rat: 64030 Monkey: 696759 |
| UniProt ID | Human: P10721 Mouse: P05532 Rat: B7SCJ0 |
| Alternative Names | PBT; SCFR; C-Kit; CD117; MASTC;mast/stem cell growth factor receptor Kit;c-Kit protooncogene;p145 c-kit;piebald trait protein;proto-oncogene c-Kit;proto-oncogene tyrosine-protein kinase Kit;tyrosine-protein kinase Kit;v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog;v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein |
Product List
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Magic™ Human KIT (A502_Y503dup) BaF3 Cell Line
[CAT#: S01YF-0324-KX162]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: KIT (A502_Y503dup) Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: BaF3 Assay Types: Functional assay and biological assay
Magic™ Human KIT (D816H) BaF3 Cell Line
[CAT#: S01YF-0324-KX163]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: KIT (D816H) Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: BaF3 Assay Types: Functional assay and biological assay
Magic™ Human KIT (D816V) BaF3 Cell Line
[CAT#: S01YF-1222-KX838]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: KIT (D816V) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human KIT (D816Y) BaF3 Cell Line
[CAT#: S01YF-0324-KX164]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: KIT (D816Y) Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: BaF3 Assay Types: Functional assay and biological assay
Magic™ Human KIT (D820Y) BaF3 Cell Line
[CAT#: S01YF-0324-KX165]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: KIT (D820Y) Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: BaF3 Assay Types: Functional assay and biological assay
Magic™ Human KIT (K642E) BaF3 Cell Line
[CAT#: S01YF-0324-KX167]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: KIT (K642E) Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: BaF3 Assay Types: Functional assay and biological assay
Magic™ Human KIT (K642E, D816A) BaF3 Cell Line
[CAT#: S01YF-0324-KX166]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: KIT (K642E, D816A) Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: BaF3 Assay Types: Functional assay and biological assay
Magic™ Human KIT (L576P) BaF3 Cell Line
[CAT#: S01YF-0324-KX168]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: KIT (L576P) Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: BaF3 Assay Types: Functional assay and biological assay
Magic™ Human KIT (W557G) BaF3 Cell Line
[CAT#: S01YF-0324-KX172]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: KIT (W557G) Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: BaF3 Assay Types: Functional assay and biological assay
Magic™ Human KIT (Y823D) BaF3 Cell Line
[CAT#: S01YF-0324-KX178]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: KIT (Y823D) Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: BaF3 Assay Types: Functional assay and biological assay
Magic™ Human KIT BaF3 Cell Line
[CAT#: S01YF-0324-KX177]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: KIT Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: BaF3 Assay Types: Functional assay and biological assay
mProX™ Human KIT Stable Cell Line
[CAT#: S01YF-1123-KX279]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: KIT Target Family: Kinases/Enzyme Drug Discovery Assays and Products Target Protein Species: Human Host Cell Type: CHO-K1; HEK293
Magic™ Human KIT (N822K) BaF3 Cell Line
[CAT#: S01YF-0324-KX169]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: KIT (N822K) Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: BaF3 Assay Types: Functional assay and biological assay
Magic™ Human KIT (V559A) BaF3 Cell Line
[CAT#: S01YF-0324-KX170]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: KIT (V559A) Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: BaF3 Assay Types: Functional assay and biological assay
Magic™ Human KIT (V559D) BaF3 Cell Line
[CAT#: S01YF-0324-KX171]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: KIT (V559D) Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: BaF3 Assay Types: Functional assay and biological assay
Magic™ Human KIT (V560G) BaF3 Cell Line
[CAT#: S01YF-1222-KX837]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: KIT (V560G) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human KIT (W557_K558del) BaF3 Cell Line
[CAT#: S01YF-0324-KX176]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: KIT (W557_K558del) Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: BaF3 Assay Types: Functional assay and biological assay
Magic™ Human KIT (W557_K558del, D816V) BaF3 Cell Line
[CAT#: S01YF-0324-KX173]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: KIT (W557_K558del, D816V) Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: BaF3 Assay Types: Functional assay and biological assay
Magic™ Human KIT (W557_K558del, T670I) BaF3 Cell Line
[CAT#: S01YF-0324-KX174]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: KIT (W557_K558del, T670I) Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: BaF3 Assay Types: Functional assay and biological assay
Magic™ Human KIT (W557_K558del, V654A) BaF3 Cell Line
[CAT#: S01YF-0324-KX175]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: KIT (W557_K558del, V654A) Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: BaF3 Assay Types: Functional assay and biological assay
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