Human KIT Membrane Protein Retroviral Expression Plasmid
[CAT#: S01YF-1124-KX993]
- Product Category:
- Membrane Protein Tools
- Subcategory:
- Membrane Protein Plasmid Products
Certificate of Analysis Lookup
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Product Information
Product Overview
This product is a made-to-order plasmid encoding human KIT for Retrovirus Production.
Target Protein
KIT
Target Protein Species
Human
Target Classification
Kinases/Enzyme
Target Research Area
Cancer Research
Related Diseases
Piebald Trait; Gastrointestinal Stromal Tumor
Target Family
Kinases/Enzyme
Vector
pRV
Vector Type
Retroviral Expression Vector
Note
Resistance
AmpR
Growth Temperature
37°C
Relevant Promoters
CMV, SV40, EF1a, CAG etc.
Mutation
Based on specific requirements
Expressed Tags
Based on specific requirements (Flag, StrepII, His, etc.)
Fluorescent Markers
EGFP, mCherry etc.
Selection Markers
Puromycin, Hygromycin, Neomycin, Blasticidin etc.
Product Properties
Applications
Retrovirus Production
Shipping
Blue Ice
Storage
Aliquot and store at -20°C for long term.
Target
Full Name
KIT proto-oncogene, receptor tyrosine kinase
Introduction
This gene encodes a receptor tyrosine kinase. This gene was initially identified as a homolog of the feline sarcoma viral oncogene v-kit and is often referred to as proto-oncogene c-Kit. The canonical form of this glycosylated transmembrane protein has an N-terminal extracellular region with five immunoglobulin-like domains, a transmembrane region, and an intracellular tyrosine kinase domain at the C-terminus. Upon activation by its cytokine ligand, stem cell factor (SCF), this protein phosphorylates multiple intracellular proteins that play a role in in the proliferation, differentiation, migration and apoptosis of many cell types and thereby plays an important role in hematopoiesis, stem cell maintenance, gametogenesis, melanogenesis, and in mast cell development, migration and function. This protein can be a membrane-bound or soluble protein. Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.
Alternative Names
KIT; PBT; SCFR; C-Kit; CD117; MASTC; mast/stem cell growth factor receptor Kit; c-Kit protooncogene; p145 c-kit; piebald trait protein; proto-oncogene c-Kit; proto-oncogene tyrosine-protein kinase Kit; soluble KIT variant 1; tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein; KIT proto-oncogene, receptor tyrosine kinase
Gene ID
UniProt ID
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