mProX™ Human INSRR Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Kinase Cell Lines
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Published Data
Fig.1 Characterization of IR mutations found in human patients.
HepG2 cells expressing either the wild-type (WT) or mutant forms of IR-GFP were starved for 14 hours, subjected to the recommended inhibitors for 4 hours, and then labeled with DAPI (blue) and anti-GFP.
Ref: Hall, Catherine, Hongtao Yu, and Eunhee Choi. "Insulin receptor endocytosis in the pathophysiology of insulin resistance." Experimental & molecular medicine 52.6 (2020): 911-920.
Pubmed: 32576931
DOI: 10.1038/s12276-020-0456-3
Research Highlights
The expression of INSRR was associated with T cells CD8, T cells gamma delta, active dendritic cells, and resting dendritic cells. INSRR is a biomarker for immune invasion prediction that is connected to the immunological microenvironment in GBM.
Zhang, Haofuzi, et al. "Identification of INSRR as an immune-related gene in the tumor microenvironment of glioblastoma by integrated bioinformatics analysis." Medical Oncology 40.6 (2023): 161.
Pubmed:
37099121
DOI:
10.1007/s12032-023-02023-8
The tyrosine kinase receptor When the extracellular medium's pH climbs above 7.9, the alkaline pH sensor known as IRR (insulin receptor-related receptor) becomes active. IRR expression is specialized; specific organs and cell types express the receptor.
Gantsova, E. A., et al. "Analysis of the Development of Insrr Knockout Mouse Preimplantation Embryos." Russian Journal of Developmental Biology 53.3 (2022): 192-197.
