FOLH1
This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms.
| Full Name | Folate hydrolase 1 |
| Gene ID | Human: 2346 Mouse: 53320 Rat: 85309 |
| UniProt ID | Human: Q04609 Mouse: O35409 Rat: P70627 Monkey: A0A2K5VNZ0 |
| Alternative Names | FOLH1; PSM; FGCP; FOLH; GCP2; PSMA; mGCP; GCPII; NAALAD1; NAALAdase; glutamate carboxypeptidase 2; N-acetylated alpha-linked acidic dipeptidase 1; N-acetylated-alpha-linked acidic dipeptidase I; NAALADase I; cell growth-inhibiting gene 27 protein; folylpoly-gamma-glutamate carboxypeptidase; glutamate carboxylase II; glutamate carboxypeptidase II; membrane glutamate carboxypeptidase; prostate specific membrane antigen variant F; pteroylpoly-gamma-glutamate carboxypeptidase; Folate hydrolase 1 |
Product List
Loading...
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: FOLH1B Target Family: Others Target Protein Species: Cyno Protein Tag: Tag-free Host Cell Type: HEK293T Assay Types: Drug screening and biological assays
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Family: Other Targets Target Protein Species: Human Host Cell Type: HEK293;CHO-K1;LNCap
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Family: Other Targets Target Protein Species: Human Host Cell Type: HEK293;CHO-K1
