mProX™ Human FOLH1B Stable Cell Line
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- Membrane Protein Stable Cell Lines
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Published Data
Fig.1 Sox7 expression negatively correlates with FOLH1 or FOLH1B expression in prostate cancer studies.
In prostate cancer studies, a negative correlation between FOLH1 or FOLH1B expression and Sox7 expression was observed, with RNA expression data retrieved from cBioPortal. The Pearson Correlation Coefficient (r) and P-value were determined via PROC CORR in SAS for Broad/Cornell and MSKCC studies, while Spearman Rank Correlation Coefficient was utilized for the TCGA study due to the non-normal data distribution. Additionally, simple linear regression (SLR) analysis was conducted to assess the direction and strength of the linear relationship between Sox7 and FOLH1 as well as Sox7 and FOLH1B, with estimates of the true slope (solid line), P-value, 95% confidence intervals (shaded area), and 95% prediction intervals (dotted line) being obtained through PROC REG in SAS.
Ref: Peng, Wei, et al. "Sox7 negatively regulates prostate-specific membrane antigen (PSMA) expression through PSMA-enhancer." The Prostate 79.4 (2019): 370-378.
Pubmed: 30488457
DOI: 10.1002/pros.23743
Research Highlights
Pisarek, Aleksandra. et al. "Epigenetic age prediction in semen - marker selection and model development." Aging, 2021.
Recent years have seen an increase in the utilization of DNA methylation analysis in both biomedical research and forensic practice. The identification of differentially methylated sites (DMSs) that exhibit varying levels of methylation throughout an individual's lifetime has led to significant advancements in molecular age estimation. Despite the common use of semen samples in forensic DNA analysis, previous studies on epigenetic age prediction have primarily focused on somatic cell types. A new study utilized Infinium MethylationEPIC BeadChip arrays to analyze DNA samples derived from semen, uncovering multiple novel DMSs that show moderate correlation with age. By validating the top ten most age-correlated DMSs, as well as three previously known markers, using targeted bisulfite massively parallel sequencing with an independent set of semen samples, the study confirmed the age-correlated nature of nine newly identified and three previously known DMSs. Prediction modelling identified a reliable model for semen, built on six CpGs from the newly identified genes.
Pisarek, Aleksandra. et al. "Epigenetic age prediction in semen - marker selection and model development." Aging, 2021.
Pubmed:
34375949
DOI:
10.18632/aging.203399
Peng, Wei. et al. "Sox7 negatively regulates prostate-specific membrane antigen (PSMA) expression through PSMA-enhancer." The Prostate, 2019.
In this study, it was found that the cis-element, PSMA enhancer (PSME), is responsible for controlling the expression of PSMA in the prostate epithelium. PSME contains several binding sites for Sox proteins, with the identification of Sox7 protein as a negative regulator of PSMA expression due to its interaction with PSME. This discovery sheds light on the role of PSME and Sox7 protein in regulating PSMA expression in the prostate epithelium.
Peng, Wei. et al. "Sox7 negatively regulates prostate-specific membrane antigen (PSMA) expression through PSMA-enhancer." The Prostate, 2019.
Pubmed:
30488457
DOI:
10.1002/pros.23743
