CSF1R
The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. Expression of a splice variant from an LTR promoter has been found in Hodgkin lymphoma (HL), HL cell lines and anaplastic large cell lymphoma.
| Full Name | colony stimulating factor 1 receptor |
| Gene ID | Human: 1436 Mouse: 12978 Rat: 307403 Monkey: 711512 |
| UniProt ID | Human: P07333 Mouse: P09581 Rat: Q00495 |
| Alternative Names | FMS; CSFR; FIM2; HDLS; C-FMS; CD115; HDLS1; CSF-1R; BANDDOS; M-CSF-R;macrophage colony-stimulating factor 1 receptor;CD115 antigen;CSF-1 receptor;FMS proto-oncogene;McDonough feline sarcoma viral (v-fms) oncogene homolog;macrophage colony stimulating factor I receptor;proto-oncogene c-Fms |
Product List
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- Product Category:
- Membrane Protein Tools
- Target Protein: CSF1R Target Family: Kinases/Enzyme Vector: pBE Vector Type: Bacterial Expression Vector
- Product Category:
- Membrane Protein Tools
- Target Protein: CSF1R Target Family: Kinases/Enzyme RNA Type: IVT mRNA Formation: In Vitro Transcription (IVT) mRNA
- Product Category:
- Membrane Protein Tools
- Target Protein: CSF1R Target Family: Kinases/Enzyme Vector: pIVT Vector Type: In Vitro Transcription (IVT) Vector
- Product Category:
- Membrane Protein Tools
- Target Protein: CSF1R Target Family: Kinases/Enzyme Vector: pIE Vector Type: Insect Expression Vector
- Product Category:
- Membrane Protein Tools
- Target Protein: CSF1R Target Family: Kinases/Enzyme Vector: pLV Vector Type: Lentiviral Expression Vector
- Product Category:
- Membrane Protein Tools
- Target Protein: CSF1R Target Family: Kinases/Enzyme
- Product Category:
- Membrane Protein Tools
- Target Protein: CSF1R Target Family: Kinases/Enzyme RNA Type: LNP-mRNA Formation: LNP Encapsulation mRNA
- Product Category:
- Membrane Protein Tools
- Target Protein: CSF1R Target Family: Kinases/Enzyme Vector: pME Vector Type: Mammalian Transient Expression Vector
- Product Category:
- Membrane Protein Tools
- Target Protein: CSF1R Target Family: Kinases/Enzyme Vector: pRV Vector Type: Retroviral Expression Vector
- Product Category:
- Membrane Protein Tools
- Target Protein: CSF1R Target Family: Kinases/Enzyme Vector: pYE Vector Type: Yeast Expression Vector
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: CSF1R Target Family: Kinases/Enzyme Drug Discovery Assays and Products Target Protein Species: Human Host Cell Type: SKBR3; CHO-K1; HEK293
