CLK2
This gene encodes a dual specificity protein kinase that phosphorylates serine/threonine and tyrosine-containing substrates. Activity of this protein regulates serine- and arginine-rich (SR) proteins of the spliceosomal complex, thereby influencing alternative transcript splicing. Chromosomal translocations have been characterized between this locus and the PAFAH1B3 (platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)) gene on chromosome 19, resulting in the production of a fusion protein. Note that this gene is distinct from the TELO2 gene (GeneID:9894), which shares the CLK2 alias, but encodes a protein that is involved in telomere length regulation. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants.
| Full Name | CDC like kinase 2 |
| Gene ID | Human: 1196 Mouse: 12748 Rat: 365842 Monkey: 717671 |
| UniProt ID | Human: P49760 Mouse: O35491 Rat: Q5XI98 |
| Alternative Names | dual specificity protein kinase CLK2;CLK kinase |
Product List
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- Product Category:
- Membrane Protein Drug Discovery In Vitro Assays
- Target Protein: CLK2 Target Family: Kinases/Enzyme Target Protein Species: Human Assay Types: Kinase Assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: CLK2 Target Family: Kinases/Enzyme Drug Discovery Assays and Products Target Protein Species: Human Host Cell Type: NSCLC; CHO-K1; HEK293
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: DCLK2 Target Family: Kinases/Enzyme Drug Discovery Assays and Products Target Protein Species: Human Host Cell Type: CHO-K1; HEK293
- Product Category:
- Membrane Protein Drug Discovery In Vitro Assays
- Target Protein: DCAMKL2 Target Family: Kinases/Enzyme Target Protein Species: Human Assay Types: Kinase Assay
