mProX™ Human CLK2 Stable Cell Line

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1122-KX1091	Magic™ Human CLK2 in Vitro Assay	Human		Kinase Assay

Product Information

Target Protein

CLK2

Target Family

Kinases/Enzyme Drug Discovery Assays and Products

Target Protein Species

Human

Host Cell Type

NSCLC; CHO-K1; HEK293

Target Classification

Kinase Cell Lines

Target Research Area

Cancer Research

Related Diseases

Prostate Cancer. Among its related pathways are Processing of Capped Intron-Containing Pre-mRNA and DNA IR-damage and cellular response via ATR

Gene ID

1196

UniProt ID

P49760

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

Two-species protein kinase The CLK2 gene in humans codes for the enzyme CLK2. A dual specificity protein kinase belonging to the CLK family is encoded by this gene. Serine/arginine-rich (SR) proteins of the spliceosomal complex have been demonstrated to connect with and be phosphorylated by members of the CLK family. This interaction is part of the regulatory mechanism that allows the SR proteins to control RNA splicing. This protein kinase may mediate the relationship between apoptosis, telomere length regulation, and cell cycle progression. It is implicated in the control of multiple cellular processes. The customized CLK2 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat Dorothy

The ordering process was smooth, and we received the CLK2 cell line in perfect condition. Dec 19 2021

chat Verified Customer

chat Barbara

The CLK2 cell line surpassed my expectations in terms of sensitivity and ease of use. It's now an essential tool in our lab, and we plan to continue using it for future projects. May 02 2021

chat Verified Customer

FAQ

Any questions about our products? Please visit our frequently asked questions page.

Published Data

Fig.1 CLK2 had a high expression in NSCLC tissues and cell lines.

qRT-PCR revealed a substantial increase in CLK2 expression in 32 lung cancer cases' tissues as compared to the control group. When comparing stage III-IV lung cancer patients to those in stage I-II, there was a significant increase in CLK2 expression.

Ref: Liu, Bing, et al. "CLK2 promotes occurrence and development of non-small cell lung cancer." Journal of the Balkan Union of Oncology 26.1 (2021): 58-64.

Pubmed: 33721432

Research Highlights

These findings suggest that EMT splicing pattern modulation and growth inhibition of breast tumors may be achieved by therapeutic targeting of CLK2.
Yoshida, Taku, et al. "CLK2 is an oncogenic kinase and splicing regulator in breast cancer." Cancer research 75.7 (2015): 1516-1526.
Pubmed: 25670169 DOI: 10.1158/0008-5472.CAN-14-2443

A significant risk of autism spectrum disorder (ASD) is one of the neurological hallmarks of Phelan-McDermid syndrome (PMDS), which is caused by SH3 and multiple ankyrin repeat domains 3 (SHANK3) haploinsufficiency.
Bidinosti, Michael, et al. "CLK2 inhibition ameliorates autistic features associated with SHANK3 deficiency." Science 351.6278 (2016): 1199-1203.
Pubmed: 26847545 DOI: 10.1126/science.aad5487