CFTR
An ATP-binding cassette (ABC) transporter superfamily member is encoded by this gene. The encoded protein regulates ion and water secretion and absorption in epithelial tissues and, unlike other members of this protein family, acts as a chloride channel. The cycles of ATP binding by the nucleotide-binding domains, regulatory domain phosphorylation, and ATP hydrolysis are what cause channel activation. Cystic fibrosis, the most prevalent deadly genetic illness among people of Northern European origin, is brought on by mutations in this gene.
| Full Name | CF transmembrane conductance regulator |
| Gene ID | Human: 1080 Mouse: 12638 Rat: 24255 Monkey: 574346 |
| UniProt ID | Human: Q20BH0 Mouse: P26361 Rat: P34158 Monkey: Q00553 |
| Alternative Names | CF; MRP7; ABC35; ABCC7; CFTR/MRP; TNR-CFTR; dJ760C5.1; cystic fibrosis transmembrane conductance regulator; cAMP-dependent chloride channel; channel conductance-controlling ATPase; cystic fibrosis transmembrane conductance regulating; cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7); CFTR; CF transmembrane conductance regulator |
Product List
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Magic™ mPro Human CFTR Cell Line
[CAT#: S01YF-1122-KX77]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: CFTR Target Family: Chloride, Ligand-Gated Target Protein Species: Human
Magic™ mPro Human CFTR Cell Line with RFP-blasticidin
[CAT#: S01YF-1122-KX144]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: CFTR Target Family: Chloride, Ligand-Gated Target Protein Species: Human
mProX™ Human CFTR Stable Cell Line
[CAT#: S01YF-1123-KX83]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: CFTR Target Family: Cystic Fibrosis Transmembrane Conductance Regulator Target Protein Species: Human Host Cell Type: A2780; SKOV3; CHO-K1; HEK293
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