CD40
This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
| Full Name | CD40 molecule |
| Gene ID | Human: 958 Mouse: 21939 Rat: 171369 Monkey: 707749 |
| UniProt ID | Human: P25942 Mouse: P27512 Rat: F6SVZ3 Monkey: F6SNI1 |
| Alternative Names | CD40; p50; Bp50; CDW40; TNFRSF5; tumor necrosis factor receptor superfamily member 5; B cell surface antigen CD40; B cell-associated molecule; CD40 molecule, TNF receptor superfamily member 5; CD40L receptor; CD40 molecule |
Product List
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- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: CD40 Target Family: CD Target Protein Species: Cyno Protein Tag: Tag-free Host Cell Type: HEK293T Assay Types: Drug screening and biological assays
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: CD40 Target Family: CD Target Protein Species: Human Host Cell Type: A20 Assay Types: Functional assay and biological assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: CD40 Target Family: CD Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: CHO-K1 Assay Types: Drug screening and biological assays
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: CD40 Target Family: Immune Checkpoint Target Protein Species: Human Protein Tag: TEV protease Host Cell Type: HEK293
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: CD40 Target Family: CD Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: HEK293T Assay Types: Drug screening and biological assays
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: CD40 Target Family: CD Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: HT1080 Assay Types: Drug screening and biological assays
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: CD40LG Target Family: CD Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: CHO-K1 Assay Types: Drug screening and biological assays
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: CD40LG Target Family: CD Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: HEK293T Assay Types: Drug screening and biological assays
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: CD40 Target Family: CD Target Protein Species: Cyno Protein Tag: Tag-free Host Cell Type: CHO-K1 Assay Types: Drug screening and biological assays
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: CD40LG Target Family: CD Target Protein Species: Mouse Protein Tag: Tag-free Host Cell Type: NIH3T3 Assay Types: Drug screening and biological assays
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Family: CD Target Protein Species: Human Host Cell Type: HEK293;CHO-K1;U87;LN229;T98G
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Family: CD Target Protein Species: Human Host Cell Type: HEK293;CHO-K1;Human T cells
