CD40
This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
| Full Name | CD40 molecule |
| Gene ID | Human: 958 Mouse: 21939 Rat: 171369 Monkey: 707749 |
| UniProt ID | Human: P25942 Mouse: P27512 Rat: F6SVZ3 Monkey: F6SNI1 |
| Alternative Names | CD40; p50; Bp50; CDW40; TNFRSF5; tumor necrosis factor receptor superfamily member 5; B cell surface antigen CD40; B cell-associated molecule; CD40 molecule, TNF receptor superfamily member 5; CD40L receptor; CD40 molecule |
Product List
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Human CD40 Membrane Protein Bacterial Expression Plasmid
[CAT#: S01YF-1124-KX710]
- Product Category:
- Membrane Protein Tools
- Target Protein: CD40 Target Family: CD Vector: pBE Vector Type: Bacterial Expression Vector
Human CD40 Membrane Protein In Vitro Transcription (IVT) mRNA
[CAT#: S01YF-1124-KX135]
- Product Category:
- Membrane Protein Tools
- Target Protein: CD40 Target Family: CD RNA Type: IVT mRNA Formation: In Vitro Transcription (IVT) mRNA
Human CD40 Membrane Protein In Vitro Transcription (IVT) Plasmid
[CAT#: S01YF-1124-KX1055]
- Product Category:
- Membrane Protein Tools
- Target Protein: CD40 Target Family: CD Vector: pIVT Vector Type: In Vitro Transcription (IVT) Vector
Human CD40 Membrane Protein Insect Expression Plasmid
[CAT#: S01YF-1124-KX480]
- Product Category:
- Membrane Protein Tools
- Target Protein: CD40 Target Family: CD Vector: pIE Vector Type: Insect Expression Vector
Human CD40 Membrane Protein Lentiviral Expression Plasmid
[CAT#: S01YF-1124-KX825]
- Product Category:
- Membrane Protein Tools
- Target Protein: CD40 Target Family: CD Vector: pLV Vector Type: Lentiviral Expression Vector
Human CD40 Membrane Protein Lentivirus
[CAT#: S01YF-1124-KX20]
- Product Category:
- Membrane Protein Tools
- Target Protein: CD40 Target Family: CD
Human CD40 Membrane Protein LNP Encapsulation mRNA
[CAT#: S01YF-1124-KX250]
- Product Category:
- Membrane Protein Tools
- Target Protein: CD40 Target Family: CD RNA Type: LNP-mRNA Formation: LNP Encapsulation mRNA
Human CD40 Membrane Protein Mammalian Transient Expression Plasmid
[CAT#: S01YF-1124-KX365]
- Product Category:
- Membrane Protein Tools
- Target Protein: CD40 Target Family: CD Vector: pME Vector Type: Mammalian Transient Expression Vector
Human CD40 Membrane Protein Retroviral Expression Plasmid
[CAT#: S01YF-1124-KX940]
- Product Category:
- Membrane Protein Tools
- Target Protein: CD40 Target Family: CD Vector: pRV Vector Type: Retroviral Expression Vector
Human CD40 Membrane Protein Yeast Expression Plasmid
[CAT#: S01YF-1124-KX595]
- Product Category:
- Membrane Protein Tools
- Target Protein: CD40 Target Family: CD Vector: pYE Vector Type: Yeast Expression Vector
Human CD40LG Membrane Protein Bacterial Expression Plasmid
[CAT#: S01YF-1124-KX711]
- Product Category:
- Membrane Protein Tools
- Target Protein: CD40LG Target Family: CD Vector: pBE Vector Type: Bacterial Expression Vector
Human CD40LG Membrane Protein In Vitro Transcription (IVT) mRNA
[CAT#: S01YF-1124-KX136]
- Product Category:
- Membrane Protein Tools
- Target Protein: CD40LG Target Family: CD RNA Type: IVT mRNA Formation: In Vitro Transcription (IVT) mRNA
Human CD40LG Membrane Protein In Vitro Transcription (IVT) Plasmid
[CAT#: S01YF-1124-KX1056]
- Product Category:
- Membrane Protein Tools
- Target Protein: CD40LG Target Family: CD Vector: pIVT Vector Type: In Vitro Transcription (IVT) Vector
Human CD40LG Membrane Protein Insect Expression Plasmid
[CAT#: S01YF-1124-KX481]
- Product Category:
- Membrane Protein Tools
- Target Protein: CD40LG Target Family: CD Vector: pIE Vector Type: Insect Expression Vector
Human CD40LG Membrane Protein Lentiviral Expression Plasmid
[CAT#: S01YF-1124-KX826]
- Product Category:
- Membrane Protein Tools
- Target Protein: CD40LG Target Family: CD Vector: pLV Vector Type: Lentiviral Expression Vector
Human CD40LG Membrane Protein Lentivirus
[CAT#: S01YF-1124-KX21]
- Product Category:
- Membrane Protein Tools
- Target Protein: CD40LG Target Family: CD
Human CD40LG Membrane Protein LNP Encapsulation mRNA
[CAT#: S01YF-1124-KX251]
- Product Category:
- Membrane Protein Tools
- Target Protein: CD40LG Target Family: CD RNA Type: LNP-mRNA Formation: LNP Encapsulation mRNA
Human CD40LG Membrane Protein Mammalian Transient Expression Plasmid
[CAT#: S01YF-1124-KX366]
- Product Category:
- Membrane Protein Tools
- Target Protein: CD40LG Target Family: CD Vector: pME Vector Type: Mammalian Transient Expression Vector
Human CD40LG Membrane Protein Retroviral Expression Plasmid
[CAT#: S01YF-1124-KX941]
- Product Category:
- Membrane Protein Tools
- Target Protein: CD40LG Target Family: CD Vector: pRV Vector Type: Retroviral Expression Vector
Human CD40LG Membrane Protein Yeast Expression Plasmid
[CAT#: S01YF-1124-KX596]
- Product Category:
- Membrane Protein Tools
- Target Protein: CD40LG Target Family: CD Vector: pYE Vector Type: Yeast Expression Vector
mProX™ Human CD40 Stable Cell Line
[CAT#: S01YF-1023-PY228]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Family: CD Target Protein Species: Human Host Cell Type: HEK293;CHO-K1;U87;LN229;T98G
mProX™ Human CD40LG Stable Cell Line
[CAT#: S01YF-1023-PY229]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Family: CD Target Protein Species: Human Host Cell Type: HEK293;CHO-K1;Human T cells
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