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    mProX™ Human CD40 Stable Cell Line

    [CAT#: S01YF-1023-PY228]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    CD Cell Lines

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    Product Information

    Target Family
    CD
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;U87;LN229;T98G
    Target Classification
    CD Cell Lines
    Target Research Area
    Immunology Research
    Related Diseases
    Immunodeficiency With Hyper-Igm, Type 3; Immunodeficiency With Hyper-Igm, Type 1
    Gene ID
    Human:958
    UniProt ID
    Human:P25942

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    CD40 agonism has potential therapeutic applications in enhancing immune-checkpoint blockade and activating effector T and NK cells to create a T cell-inflamed tumor microenvironment. It can stimulate dendritic cells, improve expansion of antigen-specific T cells, and exhibit antitumor efficacy in multiple solid tumor models. CD40-CD154 interaction is involved in the pathogenesis of inflammatory and autoimmune diseases, and the soluble CD40 receptor (sCD40) isoform may serve as a biomarker for chronic inflammatory diseases. Inflammation can induce α(1)-adrenoceptor expression in peripheral blood mononuclear cells, contributing to the inflammatory state in complex regional pain syndrome. Overall, CD40 has potential applications in cancer immunotherapy, chronic inflammatory diseases, and pain management.

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    FAQ

    chat Alex Brown (Verified Customer)

    How does CD40 influence T cell responses? Nov 09 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    CD40-CD40L interactions are vital for T cell help in immune responses, particularly in activating antigen-presenting cells and generating cytotoxic T lymphocytes. Nov 09 2022

    chat Taylor Smith (Verified Customer)

    Can CD40 agonists alter tumor stroma? Apr 19 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    CD40 agonists can modify tumor stroma, demonstrating efficacy against pancreatic carcinoma by altering the tumor microenvironment and enhancing antitumor immunity. Apr 19 2021

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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