ACVR1
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive.
| Full Name | activin A receptor type 1 |
| Gene ID | Human: 90 Mouse: 11477 Rat: 79558 Monkey: 697935 |
| UniProt ID | Human: Q04771 Mouse: P37172 Rat: P80201 |
| Alternative Names | FOP; ALK2; SKR1; TSRI; ACTRI; ACVR1A; ACVRLK2;activin receptor type-1;TGF-B superfamily receptor type I;activin A receptor, type I;activin A receptor, type II-like kinase 2;activin receptor type I;activin receptor-like kinase 2;hydroxyalkyl-protein kinase;serine/threonine-protein kinase receptor R1 |
Product List
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- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: ACVR1 Target Family: Kinases/Enzyme Drug Discovery Assays and Products Target Protein Species: Human Host Cell Type: C2C12; CHO-K1; HEK293
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: ACVR1B Target Family: Kinases/Enzyme Drug Discovery Assays and Products Target Protein Species: Human Host Cell Type: PC; CHO-K1; HEK293
