mProX™ Human ACVR1B Stable Cell Line

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1122-KX1021	Magic™ Human ACVR1B(ALK4) in Vitro Assay	Human		Kinase Assay

Product Information

Target Protein

ACVR1B

Target Family

Kinases/Enzyme Drug Discovery Assays and Products

Target Protein Species

Human

Host Cell Type

PC; CHO-K1; HEK293

Target Classification

Kinase Cell Lines

Target Research Area

Cancer Research; Cardiovascular Research

Related Diseases

Transposition Of The Great Arteries, Dextro-Looped and Pancreatic Cancer. Among its related pathways are Human Embryonic Stem Cell Pluripotency and Signal Transduction

Gene ID

UniProt ID

P36896

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The human ACVR1B gene encodes the protein known as activin receptor type-1B. Signals containing activin or activin-like ligands are transduced by ACVR1B or ALK-4. After binding to ACVR2A or ACVR2B, activin joins ACVR1B in a complex. Activins are structurally related signaling proteins that are dimeric growth and differentiation factors that are a member of the transforming growth factor-beta (TGF-beta) superfamily. A heteromeric complex of receptor serine kinases, comprising a minimum of two type I (I and IB) and two type II (II and IIB) receptors, is how activins transmit their signals. Type II receptors are necessary for ligand binding and type I receptor expression, while type I receptors are crucial for signaling. The customized ACVR1B stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat George

The ACVR1B cell line is easy to use, and the results obtained have been consistent and reliable. I would definitely recommend it to others. Mar 16 2023

chat Verified Customer

chat Carol

The ACVR1B cell line was easy to use, and the support team was responsive to our inquiries. May 02 2023

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FAQ

Any questions about our products? Please visit our frequently asked questions page.

Published Data

Fig.1 Expression of ACVR1B and SMAD4 in PC cell lines.

mRNA expression levels of the SMAD4 and ACVR1B genes in PC cell lines and normal pancreatic tissue (RNA from Clontech). Real-time RT-PCR was used to assess the expressions. The Sui65, Sui68, and Sui71 cell lines showed very little expression of ACVR1B mRNA, while the Sui65, Sui70, and Sui71 cell lines showed very little expression of SMAD4 mRNA.

Ref: Togashi, Yosuke, et al. "Homozygous deletion of the activin A receptor, type IB gene is associated with an aggressive cancer phenotype in pancreatic cancer." Molecular cancer 13.1 (2014): 1-15.

Pubmed: 24886203

DOI: 10.1186/1476-4598-13-126

Research Highlights

According to these findings, activin A enhances the neurological prognosis of ischemic stroke-affected mice by stimulating oligodendroglial ACVR1B-mediated white matter remyelination, which may offer an effective treatment approach.
Zheng, Jiayin, et al. "Activin A improves the neurological outcome after ischemic stroke in mice by promoting oligodendroglial ACVR1B-mediated white matter remyelination." Experimental Neurology 337 (2021): 113574.
Pubmed: 33345977 DOI: 10.1016/j.expneurol.2020.113574

Atrophy and muscle wasting disorders in skeletal muscle are associated with growth factors belonging to the transforming growth factor-β (TGF-β) family, including TGF-β1 and myostatin.
Hillege, Michèle MG, et al. "Lack of Tgfbr1 and Acvr1b synergistically stimulates myofibre hypertrophy and accelerates muscle regeneration." Elife 11 (2022): e77610.
Pubmed: 35323108 DOI: 10.7554/eLife.77610