mProX™ Human ACVR1 Stable Cell Line

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1122-KX1028	Magic™ Human ALK2(ACVR1) in Vitro Assay	Human		Kinase Assay

Product Information

Target Protein

ACVR1

Target Family

Kinases/Enzyme Drug Discovery Assays and Products

Target Protein Species

Human

Host Cell Type

C2C12; CHO-K1; HEK293

Target Classification

Kinase Cell Lines

Target Research Area

Ocular Research

Related Diseases

Fibrodysplasia Ossificans Progressiva and Epicanthus. Among its related pathways are ALK1 signaling events and Akt Signaling

Gene ID

UniProt ID

Q04771

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The activin receptor type-1 (ACVR1) protein, a member of the BMP type I receptor protein family, is made using instructions provided by the ACVR1 gene. BMP receptors cross the cell membrane, allowing the protein to protrude from the outside of the cell on one end while staying inside the cell on the other. Because of this configuration, receptors are able to absorb signals from the external environment and transfer them within the cell to influence its growth and operation. Numerous bodily tissues, including cartilage and skeletal muscle, contain the ACVR1 protein. It aids in the regulation of muscle and bone growth and development, including the progressive replacement of cartilage by bone. From infancy to early adulthood, this procedure is part of the natural skeletal maturation process. The customized ACVR1 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat Lena

The ACVR1 cell line I purchased was incredibly effective in my research. Sep 15 2022

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chat Bob

A very stable ACVR1 cell line, especially as there has not been much variation change during my use. Mar 09 2023

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FAQ

Any questions about our products? Please visit our frequently asked questions page.

Published Data

Fig.1 Acvr1G328V Hyperactivates BMP Signaling and Stimulates Glial Cell Proliferation

Adenoviruses expressing GFP (Ad-GFP) or GFP plus Cre (Ad-GFP-Cre) were used to transduce cells. Ad-GFP-Cre induced recombination of the conditional allele and phosphorylated SMAD1, the canonical BMP signaling effector, in Acvr1floxG328V/+ cells, but not SMAD2.

Ref: Fortin, Jerome, et al. "Mutant ACVR1 arrests glial cell differentiation to drive tumorigenesis in pediatric gliomas." Cancer Cell 37.3 (2020): 308-323.

Pubmed: 32142668

DOI: 10.1016/j.ccell.2020.02.002

Research Highlights

These findings gave rise to a potential new therapeutic approach for FOP and reveal a novel mechanism of extraskeletal bone production in the disease.
Hino, Kyosuke, et al. "Neofunction of ACVR1 in fibrodysplasia ossificans progressiva." Proceedings of the National Academy of Sciences 112.50 (2015): 15438-15443.
Pubmed: 26621707 DOI: 10.1073/pnas.1510540112

These findings reveal a new characteristic of FOP-mutant ACVR1 and suggest that anti-ACVR1 antibodies are not a suitable treatment option for FOP.
Aykul, Senem, et al. "Anti-ACVR1 antibodies exacerbate heterotopic ossification in fibrodysplasia ossificans progressiva (FOP) by activating FOP-mutant ACVR1." The Journal of Clinical Investigation 132.12 (2022).
Pubmed: 35511419 DOI: 10.1172/JCI153792