ABCB1
This gene encodes a membrane-associated protein that belongs to the superfamily of ATP-binding cassette (ABC) transporters. Different substances are transported across extracellular and intracellular membranes by ABC proteins. The MDR/TAP subfamily contains this protein as a member. The multidrug resistance of the MDR/TAP subfamily is a factor. This gene produces a protein that functions as an ATP-dependent drug efflux pump for xenobiotic substances with a wide range of substrate specificity. It controls the reduced drug accumulation in cells with multiple drug resistance and frequently controls the emergence of anticancer drug resistance. The blood-brain barrier uses this protein as a transporter as well.
| Full Name | ATP binding cassette subfamily B member 1 |
| Gene ID | Human: 5243 Mouse: 18669 Rat: 24646 Monkey: 574235 |
| UniProt ID | Human: P08183 Mouse: P06795 Rat: P43245 Monkey: H9F557 |
| Alternative Names | CLCS; MDR1; P-GP; PGY1; ABC20; CD243; GP170; p-170; ATP-dependent translocase ABCB1; ATP-binding cassette, sub-family B (MDR/TAP), member 1; P-glycoprotein 1; colchicin sensitivity; doxorubicin resistance; multidrug resistance protein 1; phospholipid transporter ABCB1; ABCB1; ATP binding cassette subfamily B member 1 |
Product List
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Magic™ Human ABCB1 MDCK Cell Line
[CAT#: S01YF-0123-KX60]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: ABCB1 Target Family: ABC Transporter Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: MDCK Assay Types: Drug screening and biological assays
mProX™ Human ABCB1 Stable Cell Line
[CAT#: S01YF-1123-KX120]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: ABCB1 Target Family: ABC Transporter Target Protein Species: Human Host Cell Type: CHO-K1; HEK293
mProX™ Human ABCB11 Stable Cell Line
[CAT#: S01YF-1123-KX121]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: ABCB11 Target Family: ABC Transporter Target Protein Species: Human Host Cell Type: CHO-K1; HEK293
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