mProX™ Human ABCB1 Stable Cell Line
[CAT#: S01YF-1123-KX120]
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Transporter Cell Lines
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Made to Order Inquiry
InquiryProduct Information
Product Properties
Biosafety Level
Level 1
Activity
Yes
Quantity
10⁶ cells per vial
Applications
In humans, the ABCB1 gene encodes the glycoprotein P-gp. Within the MDR/TAP subfamily, P-gp is a well-characterized ABC-transporter. Certain pharmaceutical medications become less effective pharmacokinetically when xenobiotics are regularly excreted back into the gastrointestinal lumen by P-gp. Furthermore, a significant amount of P-gp is expressed by certain cancer cells, which amplifies the previously mentioned effect and makes the tumors resistant to several drugs. P-gp is widely expressed and distributed. It is involved in the intestinal epithelium's function of pumping foreign substances back into the intestinal lumen, in the liver's ability to pump substances into bile ducts, in the kidney's proximal tubule cells' function of pumping substances into urine filtrate, and in the capillary endothelial cells that make up the blood-brain and blood-testis barriers' function of returning substances to the capillaries. The customized ABCB1 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.
Protocols
Please visit our protocols page.
Customer Reviews
Matthew
The ABCB1 cell line was an indispensable tool in my research. The cell line's stability and reproducibility were outstanding, allowing for reliable results across multiple experiments.
Mar 27 2022
Verified Customer
Michelle
The ABCB1 overexpression cell line has played a pivotal role in our journey of discovery.
Jul 14 2020
Verified Customer
FAQ
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