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    mProX™ Human ABCB11 Stable Cell Line

    [CAT#: S01YF-1123-KX121]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    Transporter Cell Lines

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    Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

    Sub Cat Product Name Target Protein Species Host Cell Type Assay Types Inquiry Datasheet
    S01YF-0922-KX1560 Magic™ Human ABCB11 in Vitro Drug screening assay Human Caco-2, MDCK, HEK293, CHO, membrane vesicles, and various transfected cells lines Activity Assay (High throughput screening assays; Large scale single dose, duplicate profiling; IC50 profiling; Ki determination assay; Substrate determination assay )

    Product Information

    Target Protein
    ABCB11
    Target Family
    ABC Transporter
    Target Protein Species
    Human
    Host Cell Type
    CHO-K1; HEK293
    Target Classification
    Transporter Cell Lines
    Target Research Area
    Digestive and Renal Research; Metabolic Research
    Related Diseases
    Cholestasis
    Gene ID
    8647
    UniProt ID
    O95342

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    The ABCB11 gene in humans encodes the protein ABCB11. BSEP, or sPgp, is the ABC transporter that is produced by the ABCB11 gene. The ATP-binding cassette (ABC) transporter superfamily includes this membrane-associated protein. Different substances are transported across extracellular and intracellular membranes by ABC proteins. There are seven different subfamilies of ABC genes. This protein belongs to the subfamily known as MDR/TAP. The multidrug resistance subfamily includes certain MDR/TAP members. The movement of taurocholate and other cholate conjugates from hepatocytes, or liver cells, to the bile is carried out by this specific protein. In humans, bile flow and production are mostly determined by the activity of this transporter. The customized ABCB11 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

    Protocols

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    Customer Reviews

    chat Donna

    I've used the ABCB11 cell line in multiple assays, and each time, it has exceeded my expectations. Jun 17 2022

    chat Verified Customer

    chat Cynthia

    The human ABCB11 overexpression cell line has not disappointed. It consistently delivers accurate results, making my work much more impactful. Mar 11 2023

    chat Verified Customer

    FAQ

    Any questions about our products? Please visit our frequently asked questions page.

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    • mProX™ Human ABCB11 Stable Cell Line (CAT#: S01YF-1123-KX121)
    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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