Orphan Receptor GPCR Assays

Overview of Orphan G Protein-coupled Receptors (oGPCRs)

oGPCRs are receptors that don't have any endogenous ligands. There are now about 140 GPCRs that have not been linked to endogenous ligands. They were discovered by molecular biological investigations and became the foundations of reverse pharmacology, in which receptors are sought to be matched to potential transmitters, resulting in the deorphanization of dozens of oGPCRs.

Fig.1 A schematic illustration of the oGPCRs in the CNS. (Alavi, 2018)

Functions of oGPCRs

Studies have shown that oGPCRs may perform multiple functions in the central nervous system. Furthermore, oGPCRs may have considerable effects on regulating behavioral disorders such as depression and anxiety. Notably, oGPCRs play important roles in the pathophysiology of different disorders, such as epilepsy, schizophrenia, Parkinson's disease, and Alzheimer's disease. Moreover, recent studies have identified oGPCRs as new candidate targets for addressing the deficiencies in pain treatment.

oGPCRs and Their Mechanisms

oGPCRs hold great promise as they can provide novel therapeutic targets with specificity and provide new strategies for drug design. Here, we exemplify common orphan receptors and their associated mechanisms.

Assay List of Orphan Receptors

Creative Biolabs can provide a range of assays of orphan receptors. You can choose the assay in the list or contact us for more information:

Published Data

References

1. Alavi, M. S.; et al. Orphan G protein-coupled receptors: The role in CNS disorders. Biomedicine & Pharmacotherapy. 2018; 98: 222-232.
2. Zhao, M.; et al. The Roles of Orphan G Protein-Coupled Receptors in Autoimmune Diseases. Clinical Reviews in Allergy & Immunology. 2018; 98: 222-232.