mProX™ Human UTS2R Stable Cell Line

Product Information

Target Protein

UTS2R

Target Family

Urotensin Family

Target Protein Species

Human

Host Cell Type

CHO-K1; HEK293

Target Classification

GPCR Cell Lines

Target Research Area

Cancer Research; Digestive and Renal Research

Related Diseases

Pheochromocytoma; Rhabdomyosarcoma

Gene ID

57305

UniProt ID

P49684

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

Important molecular regulators of vasoconstriction and all disorders associated with irregularities in blood pressure regulation, such as hypertension, renal ailments, and cirrhosis, include urotensin II and urotensin-II receptors. Recently, the metabolic syndrome, diabetes, and schizophrenia have all been linked to urotensin II and its receptor. According to recent research, Urotensin II and its receptor play a role in the initiation and progression of many epithelial malignancies. According to reports, the Urotensin II and Urotensin-II receptor axis controls cell growth, motility, and invasion in human breast, bladder, prostate, colorectal, and glioblastoma cancer cells. It also controls focal adhesion kinase and small Guanosine-5'-triphosphate binding proteins, which are likely involved in motility and invasion mediated by the Urotensin-II receptor. The customized UTS2R stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat Hulda

mProX™ Human UTS2R Stable Cell Line is perfect for my research. Oct 17 2022

chat Verified Customer

chat Howar

I purchased the mProX™ Human UTS2R Stable Cell Line hoping it would meet my project requirements. Nov 03 2022

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FAQ

Any questions about our products? Please visit our frequently asked questions page.

Published Data

Fig.1 The relative levels of GPCR activation as measured by the TGFα-shedding assay.

Emdesivir and urotensin-II TGFα-shedding response curves for UTS2R in the presence or absence of urantide, a UTS2R antagonist.

Ref: Ogawa, Akiko, et al. "Activation of the urotensin-II receptor by remdesivir induces cardiomyocyte dysfunction." Communications Biology 6.1 (2023): 511.

Pubmed: 37173432

DOI: 10.1038/s42003-023-04888-x

Research Highlights

Rare UTS2R mutations were strongly linked to AIS. In AIS patients, expression of UTS2R was noticeably elevated. Further research should be done on the contribution of UTS2 signaling to the creation of AIS.
Dai, Zhicheng, et al. "Novel mutations in UTS2R are associated with adolescent idiopathic scoliosis in the Chinese population." Spine 46.5 (2021): E288-E293.
Pubmed: 33156271 DOI: 10.1097/BRS.0000000000003786

According to the available research, migraineurs may experience increased oxidative damage and an inadequate antioxidant defense system during headache attacks, which may reflect changes in lymphocyte DNA damage and oxidative/antioxidative state.
Yigit, Mehmet, et al. "Oxidative/antioxidative status, lymphocyte DNA damage, and urotensin-2 receptor level in patients with migraine attacks." Neuropsychiatric disease and treatment (2018): 367-374.
Pubmed: 29416338 DOI: 10.2147/NDT.S156710