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    mProX™ Human TSHR Stable Cell Line

    [CAT#: S01YF-0923-PY83]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    GPCR Cell Lines

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    Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

    Sub Cat Product Name Target Protein Species Host Cell Type Assay Types Inquiry Datasheet
    S01YF-1122-KX521 Magic™ Mouse TSHR in Vitro cAMP Assay Mouse CHO-K1-Gqi5 cAMP Assay

    Product Information

    Target Protein
    TSHR
    Target Family
    Glycoprotein Hormone Family
    Target Protein Species
    Human
    Host Cell Type
    FTC-133;CHO-K1;HEK293
    Target Classification
    GPCR Cell Lines
    Target Research Area
    CNS Research;Metabolic Research
    Related Diseases
    Hypothyroidism, Congenital, Nongoitrous, 1;Hyperthyroidism, Familial Gestational
    Gene ID
    Human: 7253
    UniProt ID
    Human: P16473

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    Thyroid-stimulating hormone receptor (TSHR) has been extensively studied due to its pivotal role in thyroid function and its association with various pathologies. The TSH-TSHR axis has been identified as a promoter of tumor evasion in thyroid cancers and glioma, suggesting a potential therapeutic strategy in combination with immune checkpoint blockades. Moreover, CAR-T cells targeting TSHR have shown promising preclinical activity against differentiated thyroid cancer, indicating potential advancements in cancer therapy. Additionally, the role of TSHR in dedifferentiated thyroid cancer has been explored, with findings suggesting its involvement in the activation of the TSHR/cAMP/CREB/PAX8 signaling pathway. Collectively, these findings emphasize the significance of TSHR in thyroid-related disorders and its potential as a therapeutic target.

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    FAQ

    chat Brian (Verified Customer)

    How do TSHR gene mutations influence congenital hypothyroidism? Mar 17 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Two novel inactivating mutations in the TSHR gene can cause non-goitrogenic congenital hypothyroidism (CHNG) in children with CHNG. Mar 17 2022

    chat Thomas (Verified Customer)

    What is the role of the TSH-TSHR axis in tumor immune evasion? Apr 19 2023

    chat Patrick Liam (Creative Biolabs Scientific Support)

    The TSH-TSHR axis promotes tumor evasion in thyroid cancers and glioma, suggesting that TSH suppression therapy could be an effective therapeutic strategy in combination with immune checkpoint blockades. Apr 19 2023

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    • mProX™ Human TSHR Stable Cell Line (CAT#: S01YF-0923-PY83)
    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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