mProX™ Human TRPV6 Stable Cell Line

Product Information

Target Protein

TRPV6

Target Family

TRPV

Target Protein Species

Human

Host Cell Type

CHO-K1; HEK293

Target Classification

Ion Channel Cell Lines

Target Research Area

CNS Research; Cardiovascular Research

Related Diseases

Hyperparathyroidism; Transient Neonatal

Gene ID

55503

UniProt ID

Q9H1D0

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The epithelial Ca2+ channel known as Transient Receptor Potential Vanilloid subfamily member 6 (TRPV6) is a member of the transient receptor potential (TRP) protein family. TRPV5 and TRPV6 are different from the other four TRPV channels (TRPV1-TRPV4) due to their high Ca2+-selectivity. While TRPV1 through TRPV3 are heat sensors with varying temperature thresholds for activation and TRPV4 is involved in osmolarity sensing, TRPV5 and TRPV6 are involved in Ca2+ transport. Early-onset chronic pancreatitis and transitory newborn hyperparathyroidism are associated with genetic abnormalities in the TRPV6 gene. In addition, skeletal abnormalities, osteoarthritis, Pendred syndrome, male infertility, hypercalciuria, kidney stone production, bone diseases, and some subtypes of cancer are associated with dysregulation of TRPV6. The customized TRPV6 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat Elizabeth

Very easy to use for drug screening assay. Oct 31 2022

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chat Anthony

Excellent service! Very reliable. Jun 28 2020

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FAQ

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Published Data

Fig.1 Role in epithelial Ca2+ transport and functional properties of TRPV6.

Fluorescence curves obtained from HEK 293 cells that express hTRPV6 in response to varying Ca2+ concentrations (arrow).

Ref: Yelshanskaya, Maria V., et al. "Structure and function of the calcium-selective TRP channel TRPV6." The Journal of physiology 599.10 (2021): 2673-2697.

Pubmed: 32073143

DOI: 10.1113/JP279024

Research Highlights

In epithelial tissues, transient receptor potential vanilloid subfamily member 6 (TRPV6) channels that are selective for calcium are essential for calcium uptake. Modified expression of TRPV6 has been linked to numerous human illnesses, including cancer.
McGoldrick, Luke L., et al. "Opening of the human epithelial calcium channel TRPV6." Nature 553.7687 (2018): 233-237.
Pubmed: 29258289 DOI: 10.1038/nature25182

Calcium channel in the epithelium TRPV6, a member of the vanilloid subfamily of TRP channels, has inherent activity that is positively regulated by phosphoinositol and cholesterol lipids and negatively regulated by Ca2+. It is permeable to cations and highly selective to Ca2+.
Yelshanskaya, Maria V., et al. "Structure and function of the calcium-selective TRP channel TRPV6." The Journal of physiology 599.10 (2021): 2673-2697.
Pubmed: 32073143 DOI: 10.1113/JP279024