mProX™ Human TRPC6 Stable Cell Line
[CAT#: S01YF-1123-KX58]
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Ion Channel Cell Lines
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Made to Order Inquiry
InquiryProduct Information
Target Protein
TRPC6
Target Family
TRPC
Target Protein Species
Human
Host Cell Type
CHO-K1; HEK293
Target Classification
Ion Channel Cell Lines
Target Research Area
CNS Research; Digestive and Renal Research
Related Diseases
Focal Segmental Glomerulosclerosis; Nephrotic Syndrome
Gene ID
UniProt ID
Product Properties
Biosafety Level
Level 1
Activity
Yes
Quantity
10⁶ cells per vial
Applications
To encourage vasoconstriction, mechanosensation, such as cell enlargement and shear stress, can activate TRPC6 channels. GPCRs can also activate these channels. For instance, 1 nM ANG II administration activates TRPC6 channels by a process that is not dependent on PKC and is directly linked to diacylglycerol. In a fascinating work published more recently, it was suggested that Ca2 + entry via TRPC6 is essential to a force-sensing complex that supports Ca2 + release via IP3Rs on the SR to increase myogenic tone and TRPM4 channel activity. Even yet, more research is required to determine this channel's contributions to local and global Ca2 + signals, function in various vascular beds, and activation and mechanosensation mechanisms in VSM, despite the abundance of information available on it. The customized TRPC6 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.
Protocols
Please visit our protocols page.
Customer Reviews
Barbara
This cell line is perfect for my experiments.
Jun 18 2021
Verified Customer
Matthew
Professional products and professional services.
Dec 25 2022
Verified Customer
FAQ
Any questions about our products? Please visit our frequently asked questions page.
