mProX™ Human TRPC4 Stable Cell Line
[CAT#: S01YF-1123-KX56]
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Ion Channel Cell Lines
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Made to Order Inquiry
InquiryProduct Information
Target Protein
TRPC4
Target Family
TRPC
Target Protein Species
Human
Host Cell Type
U266; MM.1s; HS-5; CHO-K1; HEK293
Target Classification
Ion Channel Cell Lines
Target Research Area
CNS Research; Pain and Addiction Research
Related Diseases
Oculoectodermal Syndrome; Mutilating Palmoplantar Keratoderma
Gene ID
UniProt ID
Product Properties
Biosafety Level
Level 1
Activity
Yes
Quantity
10⁶ cells per vial
Applications
Whether TRPC4 serves as a SOC or ROC is a matter of debate. It has been proposed that AA activates TRPC4 to generate a ROC. Specifically, by employing siRNA and antisense tactics to decrease endogenous TRPC4 expression, it was demonstrated that TRPC4 is necessary for both receptor-operated and OAG-induced Ca2+ entry as well as AA-induced Ca2+ oscillations, but not for SOC function. Since AA has been found to activate a number of MS channels in the absence of applied stretch, where it appears to work by directly modifying the mechanical properties of the bilayer surrounding the channel, this activation of AA may have consequences for the mechanosensitivity of TRPC4. The customized TRPC4 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.
Protocols
Please visit our protocols page.
Customer Reviews
Amy
The web-page is easy to navigate in order to choose or customize the product.
Feb 12 2020
Verified Customer
Sharon
The Human TRPC4 Stable Cell Line is perfect for my research.
Jan 05 2021
Verified Customer
FAQ
Any questions about our products? Please visit our frequently asked questions page.
