mProX™ Human TRPC3 Stable Cell Line
[CAT#: S01YF-1123-KX55]
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Ion Channel Cell Lines
Certificate of Analysis Lookup
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
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InquiryProduct Information
Product Properties
Biosafety Level
Level 1
Activity
Yes
Quantity
10⁶ cells per vial
Applications
Through the stimulation of several G-protein-coupled receptors (GPCRs), such as ANG II and endothelin-1 (ET-1) receptors, TRPC3 in VSM has been related to the modulation of vascular tone. As a result, TRPC3 does not appear to affect intrinsic vascular tone, indicating that receptor-mediated artery vasoconstriction may be the mechanism in which TRPC3 is most important for pressure-induced tone. In fact, the mechanism of TRPC3-induced vasoconstriction in cerebral VSM involves IP3-facilitated IP3R and TRPC3 interaction. When TRPC3 is activated, cations such as Na+ and Ca2+ enter the cell, causing membrane depolarization that opens LTCCs and causes vasoconstriction. The customized TRPC3 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.
Protocols
Please visit our protocols page.
Customer Reviews
Kimberly
Creative biolabs can offer a great customized service.
Jan 08 2023
Verified Customer
William
I have always got fast and quick response from the Creative biolabs staffs.
Jul 18 2021
Verified Customer
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