mProX™ Human TACR3 Stable Cell Line

Product Information

Target Protein

TACR3

Target Family

Tachykinin Family

Target Protein Species

Human

Host Cell Type

CHO-K1; HEK293

Target Classification

GPCR Cell Lines

Target Research Area

CNS Research; Reproductive Research

Related Diseases

Hypogonadotropic Hypogonadism 11 With Or Without Anosmia; Normosmic Congenital Hypogonadotropic Hypogonadism

Gene ID

6870

UniProt ID

P29371

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The tachykinin neuropeptide neuromedin-K (also known as neurokinin B) has a receptor called TACR3 that can interact with G proteins to activate the phosphatidylinositol-calcium second messenger pathway. In the meanwhile, research on TACR3 suggests that its mutation can result in a problem with GnRH management and that it affects human fertility and the onset of puberty. Numerous disorders, including inflammatory bowel conditions, irritable bowel syndrome, squamous cell carcinoma, and gastrointestinal malignancies, have also been linked to TACR3. TACR3 plays a crucial role in physiological development, particularly in the human reproductive system. The customized TACR3 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

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I customized a TACR3 cell line and the products definitely stand out. Sep 09 2022

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Creative biolabs can offer a great customized service. Jan 24 2022

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FAQ

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Published Data

Fig.1 Functional expression and binding affinity analysis of grass carp TACR3.

The TACR1 agonist Hemokinin-1, the TACR2 agonist GR64349, and the TACR3 agonist senktide (0.1-1000 nM) were all applied to HEK-293 cells that expressed both grass carp TACR3 and CRE-Luc.

Ref: Hu, Guangfu, et al. "IGFs potentiate TAC3-induced SLα expression via upregulation of TACR3 expression in grass carp pituitary cells." Cells 8.8 (2019): 887.

Pubmed: 31412674

DOI: 10.3390/cells8080887

Research Highlights

By altering the excitability of several neurons with diverse roles, Tacr3/NK3R mediates a number of brain activities. More research on Tacr3 in additional nervous system disorders should be done in order to better understand its biological functions, according to this "excited or not" theory.
Zhang, Wen-wen, Yanqing Wang, and Yu-Xia Chu. "Tacr3/NK3R: beyond their roles in reproduction." ACS Chemical Neuroscience 11.19 (2020): 2935-2943.
Pubmed: 32926772 DOI: 10.1021/acschemneuro.0c00421

The Japanese eel was used in this investigation to examine how well NKB controlled reproduction. Two tac3 and one tacr3 genes were discovered in Japanese eels, according to the findings.
Zuo, Chenpeng, et al. "TAC3/TACR3 system function in the catadromous migration teleost, Anguilla japonica." Frontiers in Endocrinology 13 (2022): 848808.
Pubmed: 35937808 DOI: 10.3389/fendo.2022.848808