mProX™ Human TACR1 Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- GPCR Cell Lines
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Published Data
Fig.1 Anatomical organization of a Tacr1-defined spinoparabrachial circuit.
Tacr1 transcript (red), as shown by multichannel in situ hybridization, is localized to the PBN-SL. Most Tacr1-positive PBN-SL neurons are glutamatergic, making them excitatory, according to co-staining for the glutamate vesicular transporter Slc17a6 (Vglut2; cyan) and GABA vesicular transporter SLC32A1 (Vgat; green).
Ref: Barik, Arnab, et al. "A spinoparabrachial circuit defined by Tacr1 expression drives pain." Elife 10 (2021): e61135.
Pubmed: 33591273
DOI: 10.7554/eLife.61135
Research Highlights
The neurokinin-1 receptor (Tacr1) is expressed on a large number of RVM-spinal projection neurons, and substance P (SP) treatment locally activates ON cells.
Follansbee, Taylor, et al. "Inhibition of itch by neurokinin 1 receptor (Tacr1)-expressing ON cells in the rostral ventromedial medulla in mice." Elife 11 (2022): e69626.
Pubmed:
35972457
DOI:
10.7554/eLife.69626
This work provides evidence that the TACR1 gene contributes to human OA pain, which encourages future research into the gene's role in the disease.
Warner, Sophie C., et al. "Pain in knee osteoarthritis is associated with variation in the neurokinin 1/substance P receptor (TACR1) gene." European Journal of Pain 21.7 (2017): 1277-1284.
Pubmed:
28493529
DOI:
10.1002/ejp.1027
