mProX™ Human TAAR5 Stable Cell Line

Product Information

Target Protein

TAAR5

Target Family

Trace Amine Family

Target Protein Species

Human

Host Cell Type

CHO-K1; HEK293

Target Classification

GPCR Cell Lines

Target Research Area

Cancer Research; CNS Research; Orphan Receptor Research

Related Diseases

Pancreatic Somatostatinoma; Trimethylaminuria

Gene ID

9038

UniProt ID

O14804

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The TAAR5 gene in humans encodes the 38 KD protein known as the trace amine-associated receptor 5. Because recombinantly generated ''olfactory TAARs'' respond to volatile amines, including N-methylpiperidine (mTAAR7f), trimethylamine (TMA) (mTAAR5), and isoamylamine (mTAAR3), TAARs have been identified as olfactory receptors (ORs) in vertebrates. A functional trace amine-associated receptor called human TAAR5 (hTAAR5) serves as an olfactory receptor for tertiary amines. The complete agonists of hTAAR5 are trimethylamine and N, N-dimethylethylamine, while the inverse agonist of hTAAR5 is 3-iodothyronamine. Additionally, TAAR5 is nearly exclusively expressed in skeletal muscle and a few particular brain regions, including the amygdala, hippocampus, caudate nucleus, thalamus, and hypothalamus. TAAR5 is expressed in the olfactory epithelium of vertebrates. The customized TAAR5 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

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Published Data

Fig.1 TAAR5 is expressed in the mouse cerebellum and medial vestibular nuclei.

All TAAR5-KO animals examined had a distinct lacZ stain inside the cerebellum that indicated TAAR5 expression. Large spherical soma profiles and bright blue-stained cells were observed; these cells closely resembled Purkinje cells.

Ref: Kalinina, D. S., et al. "Role of the trace amine associated receptor 5 (TAAR5) in the sensorimotor functions." Scientific Reports 11.1 (2021): 23092.

Pubmed: 34845253

DOI: 10.1038/s41598-021-02289-w

Research Highlights

These findings suggest that TAAR5 is implicated in the control of adult neurogenesis, dopamine transmission, and emotional status in addition to the former two. Future TAAR5 antagonists may therefore have effects that go beyond those of antidepressants and/or sedatives to offer novel therapeutic options for neurodegenerative diseases like Parkinson's disease.
Efimova, Evgeniya V., et al. "Increased dopamine transmission and adult neurogenesis in trace amine-associated receptor 5 (TAAR5) knockout mice." Neuropharmacology 182 (2021): 108373.
Pubmed: 33132188 DOI: 10.1016/j.neuropharm.2020.108373

Cichero, Elena, et al. "A homology modelling-driven study leading to the discovery of the first mouse trace amine-associated receptor 5 (TAAR5) antagonists." MedChemComm 7.2 (2016): 353-364.