mProX™ Human TAAR1 Stable Cell Line

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1122-KX969	Magic™ Rhesus macaque TAAR1 in Vitro cAMP Assay	Rhesus monkey	CHO-K1	cAMP Assay

Product Information

Target Protein

TAAR1

Target Family

Trace Amine Family

Target Protein Species

Human

Host Cell Type

CHO-K1; HEK293

Target Classification

GPCR Cell Lines

Target Research Area

Cancer Research; CNS Research

Related Diseases

Superficial Urinary Bladder Cancer; Hypoparathyroidism-Deafness-Renal Disease Syndrome

Gene ID

134864

UniProt ID

Q96RJ0

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The six functional human trace amine-associated receptors, or TAARs, are so termed because they can bind endogenous amines, which are found in trace amounts in tissues. TAAR1 is one of these receptors. Dopamine, norepinephrine, and serotonin neurons in the CNS are regulated by TAAR1 in a major way. Additionally, it has an impact on the immunological and monoaminergic systems via several methods. The immune system's TAAR1 uses active PKA and PKC phosphorylation cascades to relay information. Methamphetamine was found to have these effects in some studies, indicating that in addition to regulating brain monoamine levels, amphetamine-related substances may also have an impact on the immune system. One of the downstream consequences of activated TAAR1 in monoaminergic systems is to elevate cAMP in the presynaptic cell by activating adenylyl cyclase via Gαs. The customized TAAR1 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

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I was very pleased with the QCs of the cell line. Jun 16 2023

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I had a wonderful encounter with this business. Excellent client service was provided. Aug 19 2022

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FAQ

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Published Data

Fig.1 Following intrastriatal or MFB 6-OHDA injection, the levels of TH and the dopamine transporter were compared in WT and TAAR1 KO mice.

Injections of striatal 6-OHDA decreased the levels of TH in the striatal tissue of mice with WT and TAAR1 KO mutations. In comparison to WT mice, TH levels were greater in the intact and lesioned hemispheres of TAAR1 KO mice.

Ref: Alvarsson, Alexandra, et al. "Modulation by trace amine-associated receptor 1 of experimental parkinsonism, L-DOPA responsivity, and glutamatergic neurotransmission." Journal of Neuroscience 35.41 (2015): 14057-14069.

Pubmed: 26468205

DOI: 10.1523/JNEUROSCI.1312-15.2015

Research Highlights

The mammalian brain exhibits widespread expression of TAAR1, particularly in limbic and monoaminergic regions thought to be involved in mood, attention, memory, fear, and addiction. Since the TAAR1 signal is primarily intracellular, it is currently unclear how TAAR1 is distributed inside cells.
Rutigliano, Grazia, Alice Accorroni, and Riccardo Zucchi. "The case for TAAR1 as a modulator of central nervous system function." Frontiers in pharmacology 8 (2018): 987.
Pubmed: 29375386 DOI: 10.3389/fphar.2017.00987

The ability of the trace amine-associated receptor 1 (TAAR1) to influence monoaminergic and glutamatergic neurotransmission has made it an attractive therapeutic target for neuropsychiatric illnesses. Due to the TAAR1-mediated control of dopaminergic tone, agonist drugs have attracted attention as potential therapies for schizophrenia and other psychoses.
Dedic, Nina, et al. "Therapeutic potential of TAAR1 agonists in schizophrenia: evidence from preclinical models and clinical studies." International Journal of Molecular Sciences 22.24 (2021): 13185.
Pubmed: 34947997 DOI: 10.3390/ijms222413185