SLC Transporter Related Drug Discovery Products
Creative Biolabs has the assays you can rely on for high throughput screening, lead optimization, characterizing and discovering targets, and uncovering the complexity of disease pathways. We can offer membrane protein in vitro assay kits that save valuable laboratory time and is ideal for high throughput screening.
Membrane protein stable cell lines are widely used in many areas of biomedical research. Creative Biolabs can offer membrane protein stable cell lines to stablish in vitro models for High Throughput Screening.
Creative Biolabs offers high-quality, innovative tools to help research groups accelerate membrane protein drug discovery. They can be found by targets. If there is no product that meets your needs, please contact us.
The solute carrier (SLC) transporter compendium comprises an expansive and heterogeneous conglomeration of membrane proteins, assuming instrumental roles in an array of biological processes, encompassing nutrient acquisition, waste expulsion, and cellular signaling modalities. Owing to their indispensable functions in physiological phenomena and drug disposition, SLC transporters have surfaced as propitious therapeutic objectives.
As a pioneer in the field of drug discovery, Creative Biolabs can offer high-quality and innovative SLC transporter tools to our customers:
Overview of SLC Transporter
Classification and Structure
The SLC transporter superfamily is the second largest group of membrane proteins, encompassing 48 distinct families classified based on sequence similarities. These transporters exhibit remarkable structural diversity, with varying numbers of transmembrane domains. Some families even function as ion channels or possess enzymatic activity, adding to the complexity of the SLC superfamily.
Fig.1 Representative modes of SLC transport.1,2
Function
The transport of numerous solutes, encompassing amino acids, sugars, ions, and various small molecules, across biological membranes is mediated by SLC transporters. These transporters play a crucial role in several physiological processes, such as amino acid accumulation, solute transportation into and out of cellular organelles, and ion flux regulation at the plasma membrane. While some SLC transporters are reliant on ion gradients for their function, others operate through solute exchange or equilibrative gating mechanisms.
Fig.2 Functional mapping of SLC transporters.3,4
SLC Transporter Drug Discovery
SLC Transporters as Drug Targets
The pivotal role of SLC transporters in modulating the absorption, distribution, metabolism, and excretion (ADME) of numerous endogenous and exogenous compounds renders them promising targets for pharmacological intervention. Several drugs, both in clinical use and under investigation, target specific SLC transporters to modulate their activity, enhance drug delivery, or circumvent drug resistance mechanisms.
Challenges and Opportunities in SLC Transporter Drug Discovery
Although SLC transporters have immense potential as therapeutic targets, various obstacles impede their successful utilization in drug discovery. These hindrances include the multi-use and redundancy of SLC transporters, probable off-target effects, and intricate regulation of their expression and activity. However, recent advancements in structural biology, functional genomics, and computational methodologies provide unparalleled prospects for the reasoned creation of SLC transporter modulators that are both selective and potent, thus paving the way for inventive therapeutics.
To summarize, Solute Carrier (SLC) transporters are a multifaceted and varied group of membrane proteins that are essential in the conveyance of various substrates across cellular membranes. The expanding comprehension of the biology and structure-function connections of SLC transporters presents enormous potential for the creation of innovative therapeutic approaches that target these critical membrane proteins. Researchers must overcome the obstacles associated with drug discovery for SLC transporters to leverage their complete potential in the pursuit of cutting-edge pharmacological interventions.
References
- Zhang, Y.; et al. The SLC transporter in nutrient and metabolic sensing, regulation, and drug development. Journal of Molecular Cell Biology. 2019, 11(1): 1-13.
- Image retrieved from Figure 2 "Representative modes of SLC transport." Zhang, et al. 2019, used under CC BY 4.0. The original image was modified by extracting and the title was changed to " Representative modes of SLC transport ".
- Colas, C., Laine, E. Targeting solute carrier transporters through functional mapping. Trends in Pharmacological Sciences. 2020, 42(1): 3-6.
- Image retrieved from Figure 2 "Functional Mapping of Solute Carrier (SLC) Transporters." Colas, et al. 2020, used under CC BY 4.0. The original image was modified by extracting and the title was changed to "Functional mapping of SLC transporters.".
