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    mProX™ Human SCN8A Stable Cell Line

    [CAT#: S01YF-1123-KX6]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    Ion Channel Cell Lines

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    Product Information

    Target Protein
    SCN8A
    Target Family
    Voltage Gated Sodium Channel
    Target Protein Species
    Human
    Host Cell Type
    CHO-K1; HEK293
    Target Classification
    Ion Channel Cell Lines
    Target Research Area
    Cardiovascular Research; CNS Research
    Related Diseases
    Myoclonus; Epileptic Encephalopathy
    Gene ID
    6334
    UniProt ID
    Q9UQD0

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    One of four voltage-gated sodium channels expressed in the mammalian brain is Nav1.6, which is encoded by SCN8A. Both the central and peripheral nervous systems include Nav1.6, which is mostly expressed in excitatory but also in inhibitory neurons. Previous research has shown that BFIE and DEEs are brought on by missense variants with gain-of-function (GOF) effects, whereas ID, ASD, and movement disorders with or without seizures are brought on by truncating variants, deletions, and some missense variants causing loss-of-function (LOF) or both LOF and GOF effects. Anti-seizure drugs (ASMs) have frequently been ineffective in treating SCN8A-related DEEs, however some patients benefit from treatment with sodium channel blockers (SCBs), particularly high-dose phenytoin. The customized SCN8A stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

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    Customer Reviews

    There are currently no Customer reviews or questions for mProX™ Human SCN8A Stable Cell Line (S01YF-1123-KX6). Click the button above to contact us or submit your feedback about this product.

    FAQ

    chat Sharon (Verified Customer)

    How do SCN8A antagonists influence neuroblastoma cells? May 08 2022

    chat Sherry Smith (Creative Biolabs Scientific Support)

    SCN8A antagonists can sensitize neuroblastoma cells to therapeutic differentiation. May 08 2022

    chat Deborah (Verified Customer)

    Where is the SCN8A expressed ? Jul 11 2021

    chat Sherry Smith (Creative Biolabs Scientific Support)

    Both the central and peripheral nervous systems include Nav1.6, which is mostly expressed in excitatory but also in inhibitory neurons. Jul 11 2021

    Related Products by Target
    • Magic™ mPro Human SCN8A Cell Line (CAT#: S01YF-1122-KX115)
    • mProX™ Human SCN8A Stable Cell Line (CAT#: S01YF-1123-KX6)
    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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