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    Family stable cell lines Voltage Gated Sodium Channel Stable Cell Lines; Innovative Tools, Membrane Protein Drug Discovery.

    mProX™ Human SCN4A Stable Cell Line

    [CAT#: S01YF-1123-KX4]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    Ion Channel Cell Lines

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    Product Information

    Target Protein
    SCN4A
    Target Family
    Voltage Gated Sodium Channel
    Target Protein Species
    Human
    Host Cell Type
    CHO-K1; HEK293
    Target Classification
    Ion Channel Cell Lines
    Target Research Area
    Cardiovascular Research; CNS Research
    Related Diseases
    Hyperkalemic Periodic Paralysis; Paramyotonia Congenita Of Von Eulenburg
    Gene ID
    6329
    UniProt ID
    P35499

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    Action potential generation and propagation require sodium channels. The most prevalent isoform in skeletal muscle, NaV1.4, is encoded by the sodium channel alpha-subunit gene (SCN4A). Mutations that affect only one SCN4A allele are frequently linked with a gain-of-function leading to periods of hyperkalemic periodic paralysis and muscular stiffness (myotonia) that may increase with repetitive contraction (paramyotonia). Family members can differ phenotypically in terms of the age of onset and clinical severity of myotonia. Another group of heterozygous SCN4A mutations result in hypokalemic periodic paralysis by allowing abnormal ion leakage through the voltage sensor of the channel rather than the sodium-conducting pore. The customized SCN4A stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

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    Customer Reviews

    There are currently no Customer reviews or questions for mProX™ Human SCN4A Stable Cell Line (S01YF-1123-KX4). Click the button above to contact us or submit your feedback about this product.

    FAQ

    chat Elizabeth (Verified Customer)

    Are there any known antagonists for SCN4A? Jun 23 2020

    chat Sherry Smith (Creative Biolabs Scientific Support)

    Yes, there are specific antagonists for SCN4A that can modulate its activity. Jun 23 2020

    chat Linda (Verified Customer)

    How does SCN4A influence cell adhesion? Apr 11 2023

    chat Sherry Smith (Creative Biolabs Scientific Support)

    SCN4A activation can influence cell adhesion molecules. Apr 11 2023

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    • mProX™ Human SCN4A Stable Cell Line (CAT#: S01YF-1123-KX4)
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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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