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    mProX™ Human SCN2A Stable Cell Line

    [CAT#: S01YF-1123-KX2]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    Ion Channel Cell Lines

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    Product Information

    Target Protein
    SCN2A
    Target Family
    Voltage Gated Sodium Channel
    Target Protein Species
    Human
    Host Cell Type
    CHO-K1; HEK293
    Target Classification
    Ion Channel Cell Lines
    Target Research Area
    Cardiovascular Research; CNS Research
    Related Diseases
    Seizures; Epileptic Encephalopathy
    Gene ID
    6326
    UniProt ID
    Q99250

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    The voltage-gated sodium channel Nav1.2, one of the principal sodium channels involved in the beginning and propagation of action potentials, is encoded by the SCN2A gene. Early in development, Nav1.2 is expressed in axon initial segments and Ranvier nodes of myelinated nerve fibers, and in the adult brain, it is found in axon initial segments and unmyelinated axons. SCN2A mutations have thus far been discovered to mostly disrupt the early stages of development, while some mutations have also been linked to later-onset neurological illnesses or a combination of both. SCN2A mutations have been discovered in individuals without epilepsy who also had intellectual disability or autistic symptoms, indicating that the gene may play a role in the etiology of autism spectrum disorders. The customized SCN2A stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

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    Customer Reviews

    There are currently no Customer reviews or questions for mProX™ Human SCN2A Stable Cell Line (S01YF-1123-KX2). Click the button above to contact us or submit your feedback about this product.

    FAQ

    chat Thomas (Verified Customer)

    Where is the SCN2A found ? Apr 17 2020

    chat Sherry Smith (Creative Biolabs Scientific Support)

    Nav1.2 is expressed in axon initial segments and Ranvier nodes of myelinated nerve fibers, and in the adult brain, it is found in axon initial segments and unmyelinated axons. Apr 17 2020

    chat Paul (Verified Customer)

    How do SCN2A stable cell lines compare to other commonly used cell lines in research? Nov 09 2021

    chat Sherry Smith (Creative Biolabs Scientific Support)

    SCN2A stabilized cell lines offer unique insights specific to their function. However, like other cell lines, their effectiveness depends on the accuracy of the stabilization process. Nov 09 2021

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    • mProX™ Human SCN2A Stable Cell Line (CAT#: S01YF-1123-KX2)
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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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