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    Family stable cell lines Voltage Gated Sodium Channel Stable Cell Lines; Innovative Tools, Membrane Protein Drug Discovery.

    mProX™ Human SCN1A Stable Cell Line

    [CAT#: S01YF-1123-KX1]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    Ion Channel Cell Lines

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    Product Information

    Target Protein
    SCN1A
    Target Family
    Voltage Gated Sodium Channel
    Target Protein Species
    Human
    Host Cell Type
    CHO-K1; HEK293
    Target Classification
    Ion Channel Cell Lines
    Target Research Area
    Cardiovascular Research; CNS Research
    Related Diseases
    Dravet Syndrome; Generalized Epilepsy
    Gene ID
    6323
    UniProt ID
    P35498

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    Voltage-gated sodium channel (VGSC) channels are crucial for the initiation and propagation of action potentials, as well as for appropriate neurological function. Nine sodium channel subunits (Nav1.1-Nav1.9) have so far been identified and confirmed. The most prevalent epileptic gene and the most common pathogenic gene in the Dravet syndrome (DS), a catastrophic and untreatable epileptic encephalopathy (EE), is SCN1A, a Nav1.1 α subunit made up of 26 coding exons and found in the 85-kb gene area. De novo SCN1A pathogenic mutations can produce a wide range of phenotypes, from seriously ill people with DS to far less severe cases of genetic epilepsy febrile seizures plus (GEFS+). The customized SCN1A stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

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    Customer Reviews

    There are currently no Customer reviews or questions for mProX™ Human SCN1A Stable Cell Line (S01YF-1123-KX1). Click the button above to contact us or submit your feedback about this product.

    FAQ

    chat Melissa (Verified Customer)

    What is the significance of SCN1A in stable cell line research? Jan 27 2023

    chat Sherry Smith (Creative Biolabs Scientific Support)

    SCN1A plays a crucial role in various cellular processes and has been the subject of numerous studies to understand its function and potential applications in research. Jan 27 2023

    chat Timothy (Verified Customer)

    Are there any known challenges or misconceptions related to SCN1A stable cell lines? Dec 14 2020

    chat Sherry Smith (Creative Biolabs Scientific Support)

    While SCN1A stable cell lines offer valuable insights, it's essential to ensure the accuracy of the stabilization process to maintain the integrity of the research findings. Dec 14 2020

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    • mProX™ Human SCN1A Stable Cell Line (CAT#: S01YF-1123-KX1)
    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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