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    mProX™ Human S1PR2 Stable Cell Line

    [CAT#: S01YF-0923-PY105]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    GPCR Cell Lines

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    Product Information

    Target Protein
    S1PR2
    Target Family
    Lysophospholipid Family
    Target Protein Species
    Mouse
    Host Cell Type
    bEnd.3;CHO-K1;HEK293
    Target Classification
    GPCR Cell Lines
    Target Research Area
    CNS Research;Cardiovascular Research
    Related Diseases
    Deafness, Autosomal Recessive 68;Rare Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb
    Gene ID
    Mouse: 14739
    UniProt ID
    Mouse: P52592

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    S1PR2 has garnered attention for its involvement in various cellular processes, including cell proliferation, migration, and angiogenesis. Recent studies have highlighted its role in renal carcinoma, where it influences the proliferation and migration of cancer cells through pathways like the S1PR2/FAK. Additionally, its association with neuroinflammation and neurotransmission alterations in conditions like hyperammonaemia has been explored. The receptor's involvement in vascular endothelial barrier function and its potential as a therapeutic target for inflammatory bowel disease further underscores its significance in health and disease.

    Protocols

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    FAQ

    chat Timothy (Verified Customer)

    How does S1PR2 influence resistance to 5-FU in colorectal cancer? Jun 18 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    S1PR2 inhibitors, such as JTE-013, have demonstrated the ability to reverse 5-FU resistance in colorectal cancer. This is achieved by blocking S1PR2 internalization to the endoplasmic reticulum (ER), which in turn inhibits the degradation of 5-FU into α-fluoro-β-alanine (FBAL) by downregulating tumoral DPD expression. Jun 18 2021

    chat Kimberly (Verified Customer)

    What role does S1PR2 play in cell migration and invasion in multiple myeloma? Dec 25 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    The downregulation of S1PR2 may contribute to the initial extramedullary translocation in multiple myeloma by promoting cell migration and invasion. This process is facilitated through the activation of the NF-κB pathway. Dec 25 2022

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