mProX™ Human PTGER1 Stable Cell Line

Product Information

Target Protein

PTGER1

Target Family

Prostanoid Family

Target Protein Species

Human

Host Cell Type

CHO-K1; HEK293

Target Classification

GPCR Cell Lines

Target Research Area

Cardiovascular Research; Pain and Addiction Research; Reproductive Research

Related Diseases

Tinea Barbae; Antenatal Bartter Syndrome

Gene ID

5731

UniProt ID

P34995

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The PTGER1 receptor performs a number of tasks. Hyperalgesia may be mediated by PTGER1. When given to the central nervous system, it increases pain perception, but when given systemically, it reduces pain perception. In addition to encouraging the growth of colon cancer in APC gene deletion and Azoxymethane-induced mice, it also encourages the development of hypertension in diabetic mice and spontaneously hypertensive rats. Furthermore, it might play a different role in the development of acute brain injuries. In rat models of neurological illnesses include ischemic stroke, epileptic seizures, surgically induced brain injury, and traumatic brain injury, pharmacological blockage or genetic deletion of the EP1 receptor produces positive or detrimental consequences. The customized PTGER1 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat Elizabeth

The PTGER1 cell line is suitable for our high-throughput drug screening. Jul 05 2023

chat Verified Customer

chat Scarlett

Very easy to use for drug screening. Mar 14 2023

chat Verified Customer

FAQ

Any questions about our products? Please visit our frequently asked questions page.

Published Data

Fig.1 PTGER1 signaling pathway.

The cell-protective action of BL001 is mediated by the PGE2 / PTGER1 signaling pathway. In islets treated or untreated with 1uM BL001, the expression levels of PTGERs were measured.

Ref: Vázquez, Eugenia Martin, et al. "NR5A2/LRH-1 regulates the PTGS2-PGE2-PTGER1 pathway contributing to pancreatic islet survival and function." Iscience 25.5 (2022).

Pubmed: 35602948

DOI: 10.1016/j.isci.2022.104345

Research Highlights

In SHRSP kids, maternal protein restriction during pregnancy alters the renal ptger1 DNA methylation state, which likely mediates the production of ptger1 and enac to cause salt sensitivity.
Miyoshi, Moe, et al. "Maternal protein restriction alters the renal Ptger1 DNA methylation state in SHRSP offspring." Nutrients 10.10 (2018): 1436.
Pubmed: 30301128 DOI: 10.3390/nu10101436

The most common clinical manifestations of NSAIDs-induced urticaria and/or angioedema (NIUA), a kind of pharmacological hypersensitivity reaction, include cross-intolerance to NSAIDs. The arachidonic acid pathway is thought to be dysregulated in certain conditions.
del Carmen Plaza-Serón, María, et al. "Copy number variation in ALOX5 and PTGER1 is associated with NSAIDs-induced urticaria and/or angioedema." Pharmacogenetics and Genomics 26.6 (20
Pubmed: 26959713 DOI: 10.1097/FPC.0000000000000216