mProX™ Human PTGDR2 Stable Cell Line

Product Information

Target Protein

PTGDR2

Target Family

Prostanoid Family

Target Protein Species

Human

Host Cell Type

HGC-27; SGC-7901; CHO-K1; HEK293

Target Classification

GPCR Cell Lines

Target Research Area

Inflammation Research; Digestive and Renal Research

Related Diseases

Eosinophilic Pustular Folliculitis; Asthma

Gene ID

309212

UniProt ID

Q6XKD3

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

One of the receptors for prostaglandin D2 (PGD2), which was initially discovered in type 2 helper T cells and is hence known as the chemoattractant receptor molecule expressed on Th2 (CRTH2), is prostaglandin D2 receptor 2 (PTGDR2). The majority of PGD2/PTGDR2 signaling research to date has been on the regulation of inflammatory responses and sleep promotion. Although PGD2 has long been known to have anticancer properties, there have only been a few investigations on how PGD2 affects tumor cell regulation. Researchers discovered that PGD2, produced by tumor stromal cells, prevented prostate cancer cells from proliferating. According to other studies, mast cell-derived PGD2 prevents angiogenesis in lung carcinoma and colon cancer that is linked to colitis. The function and regulatory mechanism of PGD2/PTGDR2 signaling in GC and CSCs, however, have not yet been fully uncovered by research. The customized PTGDR2 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat Olivia

For PTGDR2 drug discovery, this is a good choice. Jun 18 2023

chat Verified Customer

chat Alexander

The cell line is ideal for helping to detect PTGDR2. Aug 31 2022

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FAQ

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Published Data

Fig.1 PGD2/PTGDR2 signal decreased the expression of stem cell markers.

In shGFP, shL-PTGDS, or shPTGDR2 transfected SGC-7901 cells, the expression of p-STAT3(Thy705), t-STAT3, and GAPDH was assessed using a Western blot test.

Ref: Zhang, Bin, et al. "PGD2/PTGDR2 signaling restricts the self-renewal and tumorigenesis of gastric cancer." Stem cells 36.7 (2018): 990-1003.

Pubmed: 29604141

DOI: 10.1002/stem.2821

Research Highlights

Prostaglandin D2 (PGD2) has been known to have an antitumor effect on gastric cancer (GC) for many years. Cancer stem cells (CSCs) are thought to be responsible for tumor neovascularization, invasiveness, and resistance to treatment. In vitro self-renewal of GC cells can be restricted by PGD2 and its receptor (PTGDR2) signaling, and in vivo tumor development and metastasis can be inhibited.
Zhang, Bin, et al. "PGD2/PTGDR2 signaling restricts the self-renewal and tumorigenesis of gastric cancer." Stem cells 36.7 (2018): 990-1003.
Pubmed: 29604141 DOI: 10.1002/stem.2821

PTGDR2 expression levels could be used to identify asthma patients, develop a less invasive biomarker for phenotyping adult asthma, and provide more details on blood eosinophils.
García-Sánchez, Asunción, et al. "PTGDR2 expression in peripheral blood as a potential biomarker in adult patients with asthma." Journal of Personalized Medicine 11.9 (2021): 827.
Pubmed: 34575604 DOI: 10.3390/jpm11090827