mProX™ Human OXGR1 Stable Cell Line
[CAT#: S01YF-0923-KX61]
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- GPCR Cell Lines
Certificate of Analysis Lookup
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
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InquiryProduct Information
Product Properties
Biosafety Level
Level 1
Activity
Yes
Quantity
10⁶ cells per vial
Applications
OXGR1, a G-protein coupled receptor (GPCR) expressed in cortical connecting tubule and collecting duct type B intercalated cells, encodes the 2-oxoglutarate (α-ketoglutarate [AKG]) receptor 1. OXGR1 mediates cellular Ca2+ uptake in response to its ligand AKG, a recognized secondary GPCR message. When the well-established calcium NL therapy, citrate, is consumed, AKG is produced and expelled through the kidneys. According to mouse model and perfused connecting tubule research, OXGR1 signals through PKC to enhance the pendrin chloride-bicarbonate exchanger upon binding to AKG. Both Slc26a4/pendrin−/− and Oxgr1−/− mice showed reduced urine alkalinization. Pendrin mutant mice also had urinary calcium squandering, which increases the chance of developing calcium stones, along with decreased expression of the apical TRPV5 and basolateral NCX1 in the cortical connecting tubule. The customized OXGR1 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.
Protocols
Please visit our protocols page.
Customer Reviews
Edwiin
The customized OXGR1 stable cell line can be used in antibody discovery and development.
Sep 22 2023
Verified Customer
Ophelia
The cell line can be used as model systems to investigate fundamental aspects of cell biology and biochemistry.
Feb 04 2023
Verified Customer
FAQ
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