mProX™ Human NPY1R Stable Cell Line

[CAT#: S01YF-0923-PY138]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: GPCR Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types
S01YF-1122-KX692	Magic™ Rhesus monkey NPY1R in Vitro Calcium Flux Assay	Rhesus monkey	CHO-K1	Calcium Flux Assay
S01YF-1122-KX693	Magic™ Rhesus monkey NPY1R in Vitro cAMP Assay	Rhesus monkey	CHO-K1	cAMP Assay
S01YF-1122-KX694	Magic™ Rat NPY1R in Vitro Calcium Flux Assay	Rat	CHO-K1	Calcium Flux Assay
S01YF-1122-KX695	Magic™ Rat NPY1R in Vitro cAMP Assay	Rat	CHO-K1	cAMP Assay

Product Information

Target Protein

NPY1R

Target Family

Neuropeptide Y Family

Target Protein Species

Human

Host Cell Type

LX-2;CHO-K1;HEK293

Target Classification

GPCR Cell Lines

Target Research Area

Metabolic Research

Related Diseases

Body Mass Index Quantitative Trait Locus 11

Gene ID

Human: 4886

UniProt ID

Human: P25929

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

Neuropeptide Y receptor 1 (NPY1R) has been implicated in various physiological and pathological processes. Recent research has demonstrated that NPY1R mediates the inhibitory action of NPY on estradiol-stimulated growth of ER+ breast cancer cells. Its expression serves as a biomarker to predict endocrine sensitivity and survival in ER-BC patients. Another study showed that NPY1R exerts protective effects against diabetes induction. The ongoing research on NPY1R is expanding our understanding of its roles in endocrine regulation, cancer progression, and metabolic disorders.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Sandra (Verified Customer)

How is NPY1R associated with the regulation of stress and anxiety? Oct 24 2021

chat Patrick Liam (Creative Biolabs Scientific Support)

NPY1R is involved in the modulation of stress and anxiety behaviors. Variations in NPY1R genes are associated with alcohol dependence, particularly a severe subtype characterized by withdrawal symptoms. This association indicates a role of NPY1R in stress response mechanisms and emotional regulation. Oct 24 2021

chat John (Verified Customer)

Can NPY1R be linked to the progression of heart failure? Sep 15 2020

chat Patrick Liam (Creative Biolabs Scientific Support)

Yes, NPY1R is associated with adverse cardiac remodeling. The cardioprotective action of Nur77 is attributed to the inhibition of circulating NPY levels and the modulation of NPY-NPY1R signaling in cardiomyocytes. This reveals the mechanism of Nur77 as a promising modifier gene in heart failure. Sep 15 2020

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