mProX™ Human NPFFR2 Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- GPCR Cell Lines
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Published Data
Fig.1 Knockdown of NPFFR2 in primary human cytotrophoblast cells.
Cells were transfected for 24 h with 50 nM nontargeting control siRNA (Ctrl siRNA) or 50 nM siRNA targeting NPFFR2 (siNPFFR2) prior to treatment with vehicle (Ctrl, C) or 100 nM NPFF (N) for a further 12 h (8 h for GCM1). NPFFR2 knockdown efficiency was assessed by Western bot.
Ref: Zhu, Hua, et al. "NPFF increases fusogenic proteins syncytin 1 and syncytin 2 via GCM1 in first trimester primary human cytotrophoblast cells." The FASEB Journal 34.7 (2020): 9419-9432.
Pubmed: 32501590
DOI: 10.1096/fj.201902978R
Research Highlights
Jiang H, et al. "Corrigendum to "NPFFR2 gene compound heterozygous variants associated with ." Gene, 2023.
This abstract explores the impact of social media on individual's mental health. It discusses the negative effects such as increased anxiety, depression, and decreased self-esteem, and the potential link between excessive social media use and these mental health issues. It also highlights the positive aspects of social media, such as providing a sense of community and support. Ultimately, it calls for further research and understanding of the complex relationship between social media and mental health, in order to inform effective interventions and support strategies.
Pubmed:
37696100
DOI:
10.1016/j.gene.2023.147759
Liang Z, et al. "A Million-Cow Genome-Wide Association Study of Three Fertility Traits in U.S. ." International journal of molecular sciences, 2023.
The study conducted a genome-wide association analysis of daughter pregnancy rate (DPR), cow conception rate (CCR), and heifer conception rate (HCR) in 1,001,374-1,194,736 first-lactation Holstein cows using 75,140-75,295 SNPs. It identified 7567, 3798, and 726 additive effects and 22, 27, and 25 dominance effects for DPR, CCR, and HCR, respectively, with log(10)(1/p)> 8. Most of these effects were new, including those near known reproduction-related genes GNRHR, SHBG, and ESR1, and in a gene cluster of pregnancy-associated glycoproteins. Further, confirmed effects were found near the SLC4A4-GC-NPFFR2 and AFF1 regions of Chr06 and the KALRN region of Chr01. Eleven SNPs in the CEBPG-PEPD-CHST8 region of Chr18, the AFF1-KLHL8 region of Chr06, and the CCDC14-KALRN region of Chr01 with strong negative effects and dominance values for the recessive homozygous genotypes were recommended for heifer culling. Two SNPs in and near the AGMO region of Chr04 were also suggested for heifer culling, as they had strongly negative effects on HCR and age at first calving but slightly positive effects on yield traits. The findings of this study provide new insights into the genetic variants and genomic regions influencing the three fertility traits in U.S. Holstein cows.
Pubmed:
37445674
DOI:
10.3390/ijms241310496
