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    mProX™ Human NMBR Stable Cell Line

    [CAT#: S01YF-0923-PY21]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    GPCR Cell Lines

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    Product Information

    Target Protein
    NMBR
    Target Family
    Bombesin Family
    Target Protein Species
    Human
    Host Cell Type
    Primary myometrial cells;CHO-K1;HEK293
    Target Classification
    GPCR Cell Lines
    Target Research Area
    Cancer Research
    Related Diseases
    Breast Osteosarcoma;Gastrinoma
    Gene ID
    Human: 4829
    UniProt ID
    Human: P28336

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    The NMBR gene, encoding the neuromedin B receptor, has been a subject of scientific investigation due to its involvement in various physiological processes, particularly in the transmission of itch sensations. Recent studies have revealed that NMBR plays a crucial role in histaminergic itch transmission. For instance, research has shown that NMB-encoded itch is facilitated through a crosstalk mechanism involving NPRC-NMBR signaling. Furthermore, there is evidence suggesting that NMB acts exclusively through NMBR for itch transmission, while other related peptides, such as GRP, can signal through both NMBR and other receptors. Additionally, the NMBR gene has been explored in the context of neuropsychiatric disorders, with preliminary findings suggesting a potential association between NMBR variants and susceptibility to conditions like schizophrenia. In essence, NMBR has diverse applications in scientific research, with implications ranging from sensory transmission to neuropsychiatric disorders.

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    Customer Reviews

    There are currently no Customer reviews or questions for mProX™ Human NMBR Stable Cell Line (S01YF-0923-PY21). Click the button above to contact us or submit your feedback about this product.

    FAQ

    chat Cynthia (Verified Customer)

    Is NMBR only involved in itch transmission in the spinal cord? Dec 27 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    While NMBR plays a pivotal role in itch transmission in the spinal cord, it also has roles in immune responses, such as in defense against influenza A virus infection. Dec 27 2022

    chat Matthew (Verified Customer)

    Can NMBR be targeted for antipruritic interventions? Nov 24 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Yes, given its core role in itch biology, NMBR is an attractive target for antipruritic interventions. Nov 24 2021

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    • Magic™ Human NMBR CHO-K1 Cell Line, Calcium flux assay (CAT#: S01YF-1022-KX25)
    • Magic™ rat FLAG tagged NMBR C6 Cell Line, Calcium flux assay (CAT#: S01YF-1022-KX211)
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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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