mProX™ Human MTNR1B Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- GPCR Cell Lines
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Published Data
Fig.1 The expression of the insulin gene was modulated by melatonin through its interaction with the MTNR1B receptor.
Insulin release was assessed via reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and enzyme-linked immunosorbent assay (ELISA), with statistical significance denoted by *P<0.05, **P<0.01, and ***P<0.001.
Ref: Li, Yanliang, et al. "Melatonin exerts an inhibitory effect on insulin gene transcription via MTNR1B and the downstream Raf‑1/ERK signaling pathway." International journal of molecular medicine 41.2 (2018): 955-961.
Pubmed: 29207116
DOI: 10.3892/ijmm.2017.3305
Research Highlights
Skubis-Sikora A, et al. "Regulation of Adipose-Derived Stem Cell Activity by Melatonin Receptors in Terms ." Pharmaceuticals (Basel, Switzerland), 2023.
The hormone melatonin is secreted by the pineal gland and acts on Mel1A and Mel1B receptors. It has been identified to have a significant role in promoting osteogenesis during bone regeneration. Human mesenchymal stem cells derived from adipose tissue (ADSCs) have the ability to differentiate into osteoblast-like cells; however, their expansion in vitro is often limited due to decreased viability or loss of properties over time. A study was conducted to evaluate the effect of melatonin on ADSC characteristics, including its potential for osteogenic differentiation. Results showed that a 100 microM concentration of melatonin increased ADSC viability without changing its phenotype or inducing apoptosis. Furthermore, melatonin also enhanced the activity of certain osteogenesis-related genes. These findings suggest that melatonin can be safely used in regenerative medicine at low doses to improve ADSC viability without negatively impacting its osteogenic potential.
Pubmed:
37765045
DOI:
10.3390/ph16091236
Jansen EC, et al. "Early-to-mid pregnancy sleep and circadian markers in relation to birth outcomes: ." Chronobiology international, 2023.
The study by researchers revealed interesting links between maternal sleep and circadian health during pregnancy, and their effect on pregnancy outcomes. Within a pregnancy cohort of 96 women, maternal leukocyte DNA methylation of circadian genes was examined. Results showed that higher methylation of certain CpG sites within BMAL1, PER1, and MTNR1B genes were associated with lower birthweight and head circumference. Additionally, longer sleep duration during early-to-mid pregnancy was related to higher birthweight. This suggests that epigenetic mechanisms may play a role in pregnancy outcomes and warrants further investigation.
Pubmed:
37722702
DOI:
10.1080/07420528.2023.2256854
