mProX™ Human MC5R Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- GPCR Cell Lines
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Published Data
Fig.1 Influences of heightened MC5R expression on the modulation of a carefully chosen set of genes.
The mRNA levels of carefully chosen DEGs were analyzed in goose primary hepatocytes, comparing those transfected with an MC5R overexpression vector to those with an empty vector. RT-qPCR measured the fold change relative to the control group, with UBC as the reference gene. Results marked with *, **, and *** represent p-values < 0.05, 0.01, and 0.001, respectively, with n = 6.
Ref: Zhang, Jinqi, et al. "Study on the Mechanism of MC5R Participating in Energy Metabolism of Goose Liver." International Journal of Molecular Sciences 24.10 (2023): 8648.
Pubmed: 37239994
DOI: 10.3390/ijms24108648
Research Highlights
Forraz N, et al. "The World's First Acne Dysbiosis-like Model of Human 3D Ex Vivo Sebaceous Gland ." Microorganisms, 2023.
In this study, a novel model was developed to mimic acne-prone skin, incorporating a 10 ratio to C. acnes, reduced contact time, sequential inoculation, and rinsing step. Bioimaging techniques were used to demonstrate strong labeling of C. acnes in the active areas of the pilosebaceous unit. Additionally, S. epidermidis was found to form biofilm, as shown through non-specific fluorescence imaging, distributed across the sebaceous gland. Overall, this model successfully replicated the conditions of acne-prone skin, including lipid overproduction and inoculation with virulent phylotype IA C. acnes.
Pubmed:
37764027
DOI:
10.3390/microorganisms11092183
Huang Y, et al. "Solar ultraviolet B radiation promotes alpha-MSH secretion to attenuate the function ." Nature communications, 2023.
The study of the effects of ultraviolet B (UVB) radiation on human diseases has been documented. The direct relationship between solar UV radiation and type 2 lung inflammation is still unclear. A possible negative correlation between solar UVB radiation and asthmatic inflammation in humans and mice is demonstrated. Exposure to UVB induces hypothalamus-pituitary activation and regulates alpha-melanocyte-stimulating hormone (alpha-MSH) levels, resulting in suppression of allergic airway inflammation by targeting group 2 innate lymphoid cells (ILC2) through the MC5R receptor in mice. This interaction restricts ILC2 function by attenuating JAK/STAT and NF-kappaB signaling. A negative correlation between plasma alpha-MSH concentration and the number and function of ILC2s in peripheral blood mononuclear cells (PBMC) of asthmatic patients is observed. The findings shed light on how solar UVB radiation and neuroendocrine alpha-MSH contribute to restricting ILC2-mediated lung inflammation and provide a potential approach for managing allergic diseases.
Pubmed:
37699899
DOI:
10.1038/s41467-023-41319-1
