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    mProX™ Human MC4R Stable Cell Line

    [CAT#: S01YF-0923-PY119]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    GPCR Cell Lines

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    Product Information

    Target Protein
    MC4R
    Target Family
    Melanocortin Family
    Target Protein Species
    Human
    Host Cell Type
    MC3T3-E1;CHO-K1;HEK293
    Target Classification
    GPCR Cell Lines
    Target Research Area
    Metabolic Research
    Related Diseases
    Body Mass Index Quantitative Trait Locus 20;Obesity Due To Melanocortin 4 Receptor Deficiency
    Gene ID
    Human: 4160
    UniProt ID
    Human: P32245

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    The melanocortin-4 receptor (MC4R) is a G protein-coupled receptor that plays a pivotal role in regulating energy homeostasis, including appetite and energy expenditure. Mutations in the MC4R gene are the most common monogenic cause of obesity, highlighting its significance in metabolic processes. Beyond its role in energy balance, MC4R has been implicated in various physiological processes, including sexual function, blood pressure regulation, and insulin secretion. The receptor's widespread influence underscores its potential as a therapeutic target for a range of metabolic disorders. Recent studies have focused on developing MC4R agonists as potential treatments for obesity and related metabolic diseases. These agonists aim to activate the receptor, thereby reducing appetite and promoting weight loss.

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    FAQ

    chat David (Verified Customer)

    What is the association between the MC4R rs17782313 polymorphism and various physiological factors in overweight/obese individuals? Apr 10 2020

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Interactions between the CC genotype and factors such as high intakes of fat and energy, emotional eating, high appetite, and stress with elevated levels of cortisol and ghrelin can influence BMI in overweight/obese subjects. Apr 10 2020

    chat David (Verified Customer)

    How does MC4R signaling impact insulin secretion in type 2 diabetes mellitus (T2DM)? Apr 15 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Islet MC4R potentially affects PC1/3 expression via the cAMP and β-arrestin-1 pathways, regulating GLP-1 and insulin secretion. This provides a theoretical basis for targeting the molecular mechanism of T2DM. Apr 15 2022

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    • Magic™ Human MC4R CHO-K1/Gα15 Cell Line, Calcium flux assay (CAT#: S01YF-1022-KX75)
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