mProX™ Human MC1R Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- GPCR Cell Lines
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Published Data
Fig.1 The modulation of cell viability in response to ultraviolet exposure is under the governance of MC1R expression.
Stable HPM cell lines, engineered with shMC1R#1, underwent exposure to varying UVB doses. After 24 hours, cell viability was determined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay.
Ref: Robles-Espinoza, Carla Daniela, et al. "Germline MC1R status influences somatic mutation burden in melanoma." Nature communications 7.1 (2016): 12064.
Pubmed: 27403562
DOI: 10.1038/ncomms12064
Research Highlights
Su D, et al. "Melanocortin 1 receptor (MC1R) expression as a marker of progression in melanoma.." Research square, 2023.
The Melanocortin-1 receptor (MC1R) has a crucial role in human pigmentation and DNA repair mechanisms. Ongoing clinical trials are investigating the use of MC1R-targeting agents in melanoma patients, but there is a lack of large studies on the expression of MC1R in primary and metastatic melanoma tissue. Through quantitative immunofluorescence and immunohistochemistry on tissue microarrays with 225 benign nevi, 189 primary melanomas, and 271 metastatic melanomas, researchers found a gradual increase in MC1R expression as melanoma progresses. Higher levels of MC1R were associated with deeper primary lesions, ulcerated lesions, mucosal melanomas, and shorter survival in both primary and metastatic tumors. Multivariable analysis showed that Breslow thickness, ulceration, male sex, and chronic sun exposure were independent predictors of worse overall survival in primary melanoma patients, while MC1R expression and mucosal melanomas were independent predictors of inferior overall survival in the metastatic melanoma cohort. These findings suggest that MC1R may be a promising target for treating aggressive melanoma, but further studies are needed to determine its functional role in melanoma progression and its potential as a biomarker for MC1R-directed therapy.
Pubmed:
37790306
DOI:
10.21203/rs.3.rs-3314825/v1
Melo Rojas C, et al. "MC1R Gene Variants and Their Relationship with Coat Color in South American ." TheScientificWorldJournal, 2023.
The significance of fleece color as a determining factor in domestic camelids' production is well-established. Recently, research has shown a connection between variations in the MC1R gene and coat color in alpacas and llamas, specifically in the coding region. To further analyze this relationship, a study was conducted on 290 alpacas (142 white, 84 black, 50 brown, and 14 light fawn), five brown llamas, nine vicunas, and three guanacos. Nineteen polymorphisms were identified, with seven being significant, three of which were nonsynonymous (c.82A> G, c.376G> A, and c.901C> T). Interestingly, domestic camelids showed a higher number of polymorphisms compared to wild camelids, suggesting a possible link between these genetic variations and pigmentation. It was also observed that the MC1R protein plays a crucial role in determining pigmentation in alpacas.
Pubmed:
37786645
DOI:
10.1155/2023/4871135
