MC1R
The receptor protein for melanocyte-stimulating hormone is encoded by this gene without introns (MSH). The seven pass transmembrane G protein coupled receptor encoded for regulates melanogenesis. Increased pheomelanin production, which results in lighter skin and hair color, is linked to gene mutations that cause a loss of function. Pheomelanin may contribute to UV-induced skin damage by producing free radicals when exposed to UV light, but eumelanin is photoprotective. The activation of the receptor and stimulation of eumelanin production occur when MSH binds to its receptor. This receptor is a hereditary risk factor for both melanoma and non-melanoma skin cancer and a key determinant of sun sensitivity.
| Full Name | Melanocortin 1 receptor |
| Gene ID | Human: 4157 Mouse: 17199 Rat: 102552838 Monkey: 102134454 |
| UniProt ID | Human: Q01726 Mouse: Q01727 Rat: B6ZGR5 Monkey: Q864J4 |
| Alternative Names | CMM5; MSH-R; SHEP2; melanocyte-stimulating hormone receptor; MC1-R; alpha melanocyte stimulating hormone receptor; melanotropin receptor; MC1R; Melanocortin 1 receptor |
Product List
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Magic™ Human FLAG tagged MC1R HEK293T Cell Line, cAMP assay
[CAT#: S01YF-1022-KX430]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: MC1R Target Family: Melanocortin Target Protein Species: Human Protein Tag: FLAG-tag at N-terminus Host Cell Type: HEK293T Assay Types: cAMP assay
Magic™ Human MC1R CHO-K1 Cell Line with BLA (Beta-Lactamase) Reporter, Reporter Assay
[CAT#: S01YF-1222-KX81]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: MC1R Target Family: Melanocortin receptor Target Protein Species: Human Host Cell Type: CHO-K1 Assay Types: Reporter Assay
Magic™ Human MC1R CHO-K1 Cell Line, Binding and Functional Assay
[CAT#: S01YF-1222-KX307]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: MC1R Target Family: Melanocortin receptor Target Protein Species: Human Host Cell Type: CHO-K1 Assay Types: Binding and Functional Assay
Magic™ mPro Human MC1R Cell Line
[CAT#: S01YF-1122-KX38]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: MC1R Target Family: Melanocortin receptor Target Protein Species: Human
mProX™ Human MC1R Stable Cell Line
[CAT#: S01YF-0923-PY116]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: MC1R Target Family: Melanocortin Family Target Protein Species: Human Host Cell Type: Primary human melanocytes (HPMs);CHO-K1;HEK293
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