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    mProX™ Human LPAR4 Stable Cell Line

    [CAT#: S01YF-0923-PY100]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    GPCR Cell Lines

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    Product Information

    Target Protein
    LPAR4
    Target Family
    Lysophospholipid Family
    Target Protein Species
    Human
    Host Cell Type
    iPSCs;CHO-K1;HEK293
    Target Classification
    GPCR Cell Lines
    Target Research Area
    Cancer Research
    Related Diseases
    Differentiated Thyroid Carcinoma
    Gene ID
    Human: 2846
    UniProt ID
    Human: Q99677

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    LPAR4 has been identified as playing a significant role in various cancer-related processes. In pancreatic cancer, LPAR4 has been shown to promote a fibronectin-rich extracellular matrix, thereby facilitating the initiation of pancreatic cancer. Additionally, LPAR4 has been implicated in cardiac development and regeneration after myocardial infarction, suggesting its potential therapeutic applications. In the context of thyroid cancer, LPAR4 has been identified as promoting cell proliferation and migration through the class IA PI3K catalytic subunit p110β.

    Protocols

    Please visit our protocols page.

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    FAQ

    chat Stephanie (Verified Customer)

    How does LPAR4 deficiency affect the development of atherosclerosis? Jul 30 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    LPAR4 deficiency can attenuate experimental atherosclerosis. It is suggested that LPAR4 may regulate the recruitment of specific sets of macrophages or their phenotypic switching, influencing the development of atherosclerosis. Jul 30 2021

    chat James (Verified Customer)

    What role does LPAR4 play in the initiation of pancreatic cancer? Jul 28 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    LPAR4 is upregulated in pancreatic cancer cells in response to isolation stress, promoting a fibronectin-rich extracellular matrix via AKT, CREB, and integrins. This creates a niche that facilitates the initiation of pancreatic cancer. Jul 28 2022

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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